Insulin detemir

General information

Insulin detemir is a long-acting insulin analogue that lacks threonine at the B30 position and is acylated with a 14-carbon myristoyl fatty acid side-chain at the epsilon-amino group of the lysine in the B28 position. This stimulates binding to albumin and increases the half-life, extending its duration of action.

The pharmacokinetic profile of detemir does not differ in various age groups, including children. The profile is less variable than that of NPH insulin [ ].

Drug studies