Benzbromarone

General information

Benzbromarone is a benzofuran derivative chemically related to amiodarone. It increases uric acid excretion by non-specifically inhibiting its tubular reabsorption. It is used in patients with venous disorders to prevent, retard, or reverse varicose degenerative changes in the vessel wall. Benzbromarone causes diarrhea (3–4% of patients), urate and oxalate stones, urinary sand, renal colic, and allergy in a small number of patients [ , ]. Liver damage, which reverses after withdrawal, has been described [ ].