Almitrine

General information

Almitrine is a respiratory stimulant that improves hypoxemia in about 80% of patients with severe chronic obstructive pulmonary disease [ ]. Oral almitrine bimesilate (100 mg/day) increased PaO ₂ in patients with severe chronic obstructive pulmonary disease without altering mean pulmonary artery pressure [ ]. Adverse reactions were rarely observed and it was concluded that long-term treatment was safe. In other studies, respiratory, digestive, and neurological symptoms have been noted but were often pre-existent [ , ].