Introduction The differential diagnosis of microvascular syndromes involving the skin is extensive and it is critical to distinguish between inflammatory injury and non-inflammatory occlusive injury to vessels. The diagnosis of occlusive syndromes in the skin is greatly facilitated by recognizing…
Purpura Introduction The differential diagnosis of purpura is extensive, but the evaluation of a patient with purpura can be greatly facilitated by categorizing purpuric lesions into morphologic subsets . The number of lesions and their distribution pattern should also be…
Key Points The presence of a monoclonal gammopathy may be an incidental finding, but there are many cutaneous disorders that are due to or are strongly associated with the presence of a monoclonal gammopathy. A usual way to organize thinking…
Key Points Purpura has an extended and complex differential diagnosis, but can be sorted into three main pathophysiologies: simple hemorrhage, inflammatory (vessel-directed) hemorrhage, and microvascular occlusion. Recognition of patterns of morphology, number and distribution can rapidly narrow the diagnostic possibilities…
Questions Q63.1 What are two enzymes for which baseline testing serves to predict patients at risk for hematologic toxicity from drugs commonly used in dermatology? (Pgs. 690, 694, 695) Q63.2 What are some of the mechanisms by which hydroxylamine metabolites…