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Introduction Influenza viruses remain the most frequently identified causes of viral infection in the lung, and respiratory syncytial virus (RSV) remains a major cause of severe pneumonia in children worldwide and is an increasingly recognized cause of illness in adults…

This chapter is directed to pathologists who are confronted by certain viral infections of the central nervous system (CNS) that may have systemic involvement. The arboviral encephalitides and CNS infections caused by DNA viruses have been covered in other chapters.…

The findings and conclusions in this work are those of the author and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Introduction Overview of Viral Encephalitis Infections of the central nervous system (CNS)…

Influenza Viruses Influenza A and B viruses are antigenically, ecologically, and epidemiologically distinct members of the family Orthomyxoviridae that have segmented, negative-sense RNA genomes and are surrounded by a lipid envelope. Globally, both virus groups are associated with an enormous…

## Within the past century, pandemic infections, including the 1918 influenza pandemic, human immunodeficiency virus (HIV)-acquired immunodeficiency syndrome (AIDS), H1N1 ‘swine’ influenza, Zika virus and, at the time of writing, SARS-CoV-2, remind us how the ease and frequency of worldwide…

Introduction During the last two decades, the approach to histopathologic diagnosis has been dramatically transformed by immunohistochemistry, specifically in the diagnosis and classification of tumors and, more recently, in the diagnosis of infectious diseases in tissue samples. Pathologists play an…