The human heart is a remarkably efficient, durable, and reliable pump, propelling more than 7500 L of blood through the body each day, and beating more than 40 million times a year—the wellspring for tissue oxygenation, nutrition, and waste removal. In…
Vascular pathology is responsible for more morbidity and mortality than any other category of human disease. Although the most clinically significant lesions involve arteries, venous disorders are not inconsequential. Two principal mechanisms underlie vascular disease: Narrowing (stenosis) or complete obstruction…
Pathology literally translates as the study of suffering (Greek pathos = suffering, logos = study); more prosaically, and as applied to modern medicine, it is the study of disease. Virchow was prescient in asserting that disease originates at the cellular…
Central concept figure: evolution of cell therapy for myocardial repair and regeneration Introduction The late 1990s and early 2000s was a time period when major advances in stem cell biology were occurring . In this milieu, the concept of cell-based…
Open full size image Central concept figure The cardiovascular system can be impacted by a number of different genetic diseases (inner ring). There are numerous types of alterations to the human genome associated with these diseases (outer ring). The techniques…