Open full size image Investigative information Investigation of sudden cardiac death (SCD), like all other sudden, unexpected, or unnatural death, relies heavily on a thorough and comprehensive investigation of the circumstances surrounding death, including a scene investigation, interview with family…
Central concept figure: evolution of cell therapy for myocardial repair and regeneration Introduction The late 1990s and early 2000s was a time period when major advances in stem cell biology were occurring . In this milieu, the concept of cell-based…
Open full size image General clinicopathologic considerations Cardiac transplantation is an accepted therapeutic option which provides long-term survival for many patients with end-stage heart failure. Over 140,000 heart transplants at over 400 centers worldwide were recorded by the International Society…
Open full size image Incidence and classification Cardiac tumors are rare and when they occur, they are most frequently benign. The autopsy incidence of primary cardiac tumors varies greatly by study with estimates ranging from 0.001% to 0.3% and a…
Central concept figure: comprehensive medical device pathology Introduction The last several decades have witnessed a virtual explosion in the armamentarium of interventional and surgical procedures and medical devices available to manage cardiovascular diseases. For example, percutaneous treatment of coronary artery…
Open full size image With a worldwide prevalence of over 100 million cases, valvular heart disease remains a significant human and clinical burden, necessitating over an estimated 400,000 interventions annually worldwide and estimated to surpass 850,000 by 2050 . Three…
Open full size image Normal pericardium Structure Anatomy The pericardium is a bilayered sac-like structure surrounding the heart and the origin of the large blood vessels. The outer layer of this sac is called the parietal pericardium, which consists of…
Open full size image Open full size image Open full size image Open full size image Definition and classification of cardiomyopathies The definition and classification of cardiomyopathies (CMPs) has been subject to revision for more than 30 years. In 1980,…
Open full size image Introduction Drug reactions are some of the most frequently encountered adverse complications in the hospital setting. As many as 30% of hospitalized patients may experience such a reaction, and an estimated one to two million Americans…
Open full size image (A) Arrhythmogenic cardiomyopathy: the arrhythmic killer is the fibrofatty replacement of the right ventricle (B) Hypertrophic cardiomyopathy: myocardial disarray is the substrate of the fatal tachyarrhythmia (C) The histology of coronary vasospasm: transient ST segment elevation,…