Knowledge of the pathobiology of atherosclerosis has continued to evolve at a rapid pace. Previously regarded as a mainly segmental disease, we now increasingly appreciate the condition’s diffuse nature. The traditional clinical focus on atherosclerosis has emphasized coronary artery disease.…
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Evolution of Concepts Regarding Mechanisms of Myocardial Infarction Historical Perspective The scientific study of the mechanisms of myocardial infarction (MI) occurred surprisingly recently. Heberden published his strikingly contemporary description of angina pectoris in 1772. The very first article in the…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Atherosclerotic cardiovascular diseases (ASCVDs) represent a major burden to society and on national health care systems. Despite public health measures aimed at decreasing saturated fat consumption and cigarette smoking…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Overview Trends in Cardiovascular Disease and Risk Factors Global Trends Cardiovascular disease remains the leading cause of death worldwide, accounting for approximately 18 million deaths in 2017, with most…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Overview and Background The 20th century witnessed a remarkable evolution in concepts concerning the pathogenesis of atherosclerosis. This disease has a venerable history, having left traces in the arteries…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Clinicians use biomarkers daily in the practice of cardiovascular medicine. Moreover, the use of biomarkers can continue to improve physicians’ ability to provide clinically effective and cost-effective cardiovascular medicine…