Introduction There are two concerns in drug safety: drug reactions and drug interactions. When multiple medications are prescribed, drug interactions become an important safety and efficacy consideration for patients and physicians alike . Non-prescription drugs, as well as herbal or…
Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports Open full size image Drug eruptions are among the most frequent adverse reactions in…
Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports Open full size image Drug reaction with eosinophilia and systemic symptoms (DRESS), also known…
Key Points Prevent harm: Be aware of high-risk drugs and always consider a drug reaction as part of a differential diagnosis. Monitoring: Monitor for systemic involvement. Diagnosis: Determine the morphology of the eruption and decide if it is simple or…
Questions Q67.1 Which drugs or drug groups most commonly induce the drug reaction with eosinophilia and systemic symptoms (DRESS)? (Pg. 743) Q67.2 Which anticonvulsants have the potential to cause DRESS; to which category do all but one of these anticonvulsants…
Questions Q66.1 What are several drugs with a narrow therapeutic index, which increases the likelihood of relatively serious drug interactions? (Pg. 726) Q66.2 Which drugs are highly protein bound, increasing the likelihood of significant increases in free drug concentrations, when…