Definition A variant of invasive prostatic carcinoma that is morphologically characterized by pseudostratified columnar epithelium, typically arranged in dilated glands with flat or tufted epithelium, and morphologic features that resemble high-grade prostatic intraepithelial neoplasia (HGPIN) but lack basal cells. Some…
Definition A deceptively bland variant of invasive Gleason pattern 3 prostatic carcinoma that is morphologically characterized by dilated (i.e., microcystic) acini (up to 10 times the size of a normal Gleason pattern 3 cancer gland) and bland cytology. Could also…
Definition The diagnosis of mucinous adenocarcinoma of the prostate is established only when extracellular mucin is secreted in sufficient quantity to result in pools of mucin (i.e., colloid-like carcinoma) involving more than 25% of the tumor volume on radical prostatectomy.…
Definition A benign lesion of the prostate characterized by a biphasic population of small-sized glands and a cellular and/or hyalinized spindled cell stroma, the former of which can show myoepithelial differentiation (i.e., a metaplastic process). Clinical features You’re Reading a…
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D efinition — Bleeding under low pressure into the placental parenchyma of fetal origin. Clinical Features Epidemiology Cause is unknown. Rarely severe, with massive fetal to maternal hemorrhage. You’re Reading a Preview Become a Clinical Tree membership for Full access…
D efinition — Abnormalities in distal villous maturation that occur late in pregnancy and are emblematic of underperfusion, including increased syncytial knots, distal villous hypoplasia (DVH), aggregated terminal villi, and chorangiosis. Clinical Features Epidemiology Seen as abnormal development of the…
D efinition — Discoloration of the placenta and membranes due to staining with meconium. Clinical Features Epidemiology Meconium release is a relatively common event in term deliveries. Much debate exists about the pathologic nature of meconium and whether it represents…
D efinition — Infarction of the fetal villi due to lack of intervillous perfusion. Clinical Features Epidemiology Localized infarction within term placentas is very common. Abnormal infarction occurs in the setting of the intervillous hemorrhage of abruption, thrombosis, or vasoconstriction…
D efinition — A hypertensive disorder that arises during pregnancy; there are five types. Clinical Features Epidemiology Hypertensive disorders that fall under the umbrella of “toxemia of pregnancy” are common occurrences. Their presentations are varied and described in the following…