D efinition — An early, noninvasive form of serous adenocarcinoma of the endometrium. Clinical Features Epidemiology Serous endometrial intraepithelial carcinoma (EIC) is a rare neoplasm. The vast majority of patients are postmenopausal. EIC is most commonly seen in a background…
D efinition — Epithelial proliferations with evidence of p53 mutations that do not fulfill the criteria for intramucosal carcinoma. Clinical Features Epidemiology These lesions are rare and occur around menopause. Occasionally seen in endometrial polyps. Link between p53 positive epithelium…
D efinition — Nonepithelial cells present during both benign and neoplastic conditions. Clinical Features Epidemiology/Significance Histiocytes are common in postmenopausal endometrial samples, often associated with surface injury or erosion. They do not confer an increased risk of malignancy. Foamy stromal…
D efinition — Implants of keratinous material within the peritoneal cavity causing an associated granulomatous response. Clinical Features Epidemiology Overall, peritoneal keratin granulomas are an uncommon finding; however, they most commonly occur in patients with gynecologic tumors. The most common…
D efinition — A diagnostic conundrum influencing management and outcome. Presentation Abnormal uterine bleeding or postmenopausal bleeding is the most common presenting sign. Increased age at the time of postmenopausal bleeding is associated with increased incidence of carcinoma. The risk…
D efinition — Adenocarcinoma arising in the lower uterine segment (LUS). Clinical Features Epidemiology Uncommon variant of endometrial adenocarcinoma, accounting for from 3% to 6%. Associated with Lynch syndrome in up to 29% versus approximately 2% of conventional endometrial adenocarcinoma.…
D efinition — Adenocarcinoma of the endometrium that maintains some histologic features of normal endometrium. Clinical Features Epidemiology Endometrioid endometrial carcinoma (EMCA) is the most common form of gynecologic malignancy. The overall lifetime incidence is between 2% and 3%. The…
D efinition — A microacinar arrangement of endometrioid epithelium seen in endometrial biopsies/curettings that signifies the presence of endometrial neoplasia. Clinical Features Epidemiology Most commonly occurs in postmenopausal women in their sixth and seventh decades. You’re Reading a Preview Become…
D efinition — Alteration of the epithelial cells consisting of tubular differentiation, including oxyphilic cytoplasm. Clinical Features Epidemiology Tubal metaplasia is common, although clonal expansions of tubal metaplasia are less so. Eosinophilic metaplasia is an uncommon entity. Both tubal and…
D efinition — An endometrial malignancy composed almost entirely of squamous carcinoma. Clinical Features Epidemiology Rare, comprises less than 1% of uterine endometrial carcinomas. Most commonly occurs in postmenopausal women in their seventh and eighth decades. Usually not associated with…