D efinition — A highly malignant neoplasm composed of malignant glandular and stromal elements. Clinical Features Epidemiology Occurs almost exclusively in women over 60 years of age. An association with prior radiation has been described. Some studies show an increased…
D efinition — A problematic endometrioid carcinoma with some clear-cell features. Clinical Features Epidemiology Similar to other endometrioid carcinomas. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are…
D efinition — A high-grade, malignant neoplasm of the endometrium. Clinical Features Epidemiology Clear-cell carcinoma of the endometrium is a rare malignancy comprising less than 1% of all endometrial cancers. You’re Reading a Preview Become a Clinical Tree membership for…
D efinition — Poorly differentiated carcinomas in which a line of differentiation cannot be determined. Clinical Features Epidemiology Pure undifferentiated carcinomas are rare. Patients may present at a wide range of ages, with a mean age of 63 years. You’re…
D efinition — A variant of endometrioid carcinoma with neuroendocrine features. Clinical Features Epidemiology A variant pattern seen in poorly differentiated carcinomas of the endometrium. The vast majority of patients are postmenopausal with a median age in the sixth to…
D efinition — A common conundrum in endometrial cancer classification in which an endometrioid histology coexists with strong p53 staining. Clinical Features Epidemiology Outcomes for serous carcinoma are distinctly less favorable relative to both low- and high-grade endometrioid carcinomas. Some…
D efinition — A variant of endometrial carcinoma with two distinct differentiation patterns, usually separated, with minimal evidence of a histologic transition. Clinical Features Epidemiology Relatively uncommon. Can occur at any age. Presumed to be a single original clone followed…
D efinition — High-grade adenocarcinoma arising from the endometrium and invariably associated with mutations in the p53 tumor suppressor gene. Clinical Features Epidemiology Uterine serous carcinoma is relatively uncommon, comprising around 10% of endometrial primaries. Patients are most commonly in…
D efinition — A form of atypia associated with abnormal bleeding. Clinical Features Epidemiology Most commonly occurs in women in their fifth to seventh decades. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
D efinition — A form of hobnail atypia associated with adjacent necrosis or hyaline degeneration signifying regional ischemia. Clinical Features Epidemiology Most commonly occurs in women in their fifth to seventh decades who have endometrial polyps. You’re Reading a Preview…