This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 125.1 . Key Concepts Addiction has been a major problem worldwide for decades. Alcoholism remains the most widely abused substance, with prescription opiates becoming as…
Key Concepts A classic model of basal ganglia circuitry is used to describe the essential neurophysiology of Parkinson’s disease. This model involves two parallel and antagonistic basal ganglia circuits: the direct and indirect pathways. The direct pathway is responsible for…
Movement disorders, such as Parkinson disease (PD), are currently treated pharmacologically by systemic administration of drugs that replace, mimic, or potentiate lost neurotransmitters, and more recently with neurosurgical procedures such as deep brain stimulation (DBS) of the subthalamic nucleus (STN)…
Introduction One billion people worldwide have a neurologic disorder ( ), and despite great demand for effective therapies, treatment options for these disorders remain quite limited. Interventions to deliver genes to the nervous system that permanently restore function are a…