This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 144.1 . Key Concepts MRI is the primary imaging modality for brain tumor detection and characterization. CT is a useful imaging modality to evaluate bone…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 143.1 . Key Concepts The neurological complications of cancer include headaches, seizures, focal neurological symptoms, and cognitive and behavioral changes. Paraneoplastic neurological syndromes may precede…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 142.1 . Key Concepts Risks of gliomas and meningiomas vary significantly across sex, age, histology, ethnicity, and geography. The incidences of glioblastoma (the most common…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 141.1 . Key Concepts A combination of tight junctions and neighboring astrocytes in the blood-brain barrier (BBB) creates a significant obstacle in the effective delivery…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 140.1 . This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 140.1 . Key Concepts Anti–vascular endothelial growth factor…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 139.1 . Key Concepts Melanomas and lung, breast, colorectal, and renal cancers show the most proclivity for the brain, followed more uncommonly by thyroid, gastrointestinal…
Key Concepts The malignant glioma microenvironment is infiltrated by multiple types of immune cells, including myeloid cells and microglia, which are a significant component of these tumors. These cells contribute to immunosuppression and facilitate tumor cell invasion of normal brain.…
This chapter includes an accompanying lecture presentation that has been prepared by the author: Video 137.1 . Key Concepts The basis of CNS malignancies is DNA mutations in genes that regulate cell fate, survival, and genome maintenance. Most commonly these…
Acknowledgment We sincerely thank Dr. Ali Ravanpay for his work on the previous edition of this chapter, which was critical for the updates provided in this new version. This chapter includes an accompanying lecture presentation that has been prepared by…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 135.1 . Key Concepts Glioblastoma multiforme cells are hierarchically organized with brain tumor stem cells (BTSCs) on top. BTSCs have stem cell properties and are…