Key Points Curth’s postulates provide a group of criteria that are helpful to determine whether a skin condition is likely to be related to an internal malignancy. Individual paraneoplastic skin conditions tend to be associated more frequently with certain types…
Key Points Classic dermatomyositis involves a proximal inflammatory myopathy with a characteristic cutaneous eruption. In patients with clinically amyopathic dermatomyositis, skin disease is the prominent feature. Pathognomonic cutaneous findings of dermatomyositis include the heliotrope eruption and Gottron’s papules. In dermatomyositis,…
Key Points Lupus erythematosus is a multisystem disorder that frequently has cutaneous involvement Lupus-specific skin disease can be characterized as acute, subacute, or chronic based on clinical and laboratory features Other nonspecific cutaneous changes such as cutaneous vasculitis and Raynaud’s…
Questions Q21.1 What are the proposed mechanisms by which antimalarials work in various dermatoses discussed in this chapter? (Pg. 236) Q21.2 In general, concerning responses of lupus erythematosus to antimalarials, (1) which cutaneous subsets respond well, (2) which cutaneous subsets…
Questions Q14.1 What are the proposed mechanisms by which methotrexate inhibits inflammatory dermatoses? (Pg. 159×4) Q14.2 What is the biochemical rationale behind the use of (1) folinic acid, and/or (2) thymidine in patients with acute methotrexate liver toxicity (especially pancytopenia)?…
Key Points Internal malignancy can involve the skin either directly or indirectly. Direct involvement is defined as tumor metastatic to the skin. Indirect involvement refers to changes in the skin that suggest the possibility of an underlying malignancy. Patients with…