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Introduction Until the beginning of 20th century, it was believed that coronary thrombosis was always immediately fatal. In 1910, two Ukrainian physicians described five patients with acute myocardial infarction (MI), in whom three were found to have coronary thrombosis at…

Ischemic heart disease may manifest clinically as either chronic stable angina (see Chapter 40) or an acute coronary syndrome (ACS). The spectrum of ACS includes ST-segment elevation myocardial infarction (STEMI) (see Chapters 37 and 38) and the non–ST elevation acute…

Additional content is available online at Elsevier eBooks for Practicing Clinicians The Birth Although the heart was recognized as a vital organ in early human history, its function was not understood but was widely debated over millennia. In 1628, William…