David E. Haines Archives

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Dorchester Center, MA 02124

Cryoablation and Other Radiofrequency Alternatives

Cryoablation Mechanism of Tissue Injury Cryoablation is the removal of heat that results in destruction of tissue. Cryotherapy was invented to treat cancers in the mid 19th century. Cryoablation causes tissue damage by direct and indirect mechanisms: the direct mechanism…

Biophysics and Pathophysiology of Radiofrequency Lesion Formation

Key Points Radiofrequency (RF) energy induces thermal lesion formation through resistive heating of myocardial tissue. Tissue temperatures of 50°C or higher are necessary for irreversible injury. Under controlled conditions, RF lesion size increases with increasing delivered power, electrode–tissue interface temperature,…