D efinition — A trophoblastic malignancy composed of syncytiotrophoblasts and cytotrophoblasts, intermediate trophoblasts of both. Clinical Features Epidemiology At least half of choriocarcinomas follow a molar pregnancy, but only 2% to 3% of complete moles are followed by a diagnosis…
PITFALL D efinition — An abnormally large placenta characterized by striking, cystically dilated stem villi, stromal overgrowth, and hypervascularity. Clinical Features Epidemiology Rare; case reports only. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy…
D efinition — Gestational trophoblastic disease in which the conceptus contains a triploid (3n) amount of genetic material (typically 1n maternal and 2n paternal). Clinical Features Epidemiology Partial moles are 10 times more common than complete moles. The risk factors…
D efinition —A complete mole that invades into the underlying myometrium. Clinical Features Epidemiology Is defined as an uncommon sequel to complete mole, occurring in less than 5% of complete moles. Increased incidence has been noted in women of Asian…
PITFALL D efinition — An abnormal gestation in which all of the genetic material is paternally derived. Clinical Features Epidemiology Molar pregnancies have a biphasic age distribution, with increased incidence at the reproductive extremes: before age 20 and after age…
D efinition — Implantation of the embryo that occurs outside the uterine cavity or in an abnormal location within the uterus. Clinical Features Epidemiology Ectopic pregnancies account for around 2% of all documented pregnancies in the United States. Ectopic pregnancy…
D efinition — Unavoidable loss of viability in the first 12 weeks. Clinical Features Epidemiology Approximately one third of clinically known pregnancies terminate in the first 12 weeks. Forty to fifty percent have a chromosomal anomaly. Twenty percent have trisomy…
D efinition — A collection of extravillous trophoblasts within hyalinized stroma, indicative of a previous pregnancy. Clinical Features Epidemiology Implantation site nodules are common and typically have the same immunophenotype as epithelioid trophoblasts seen in the membranes, maternal surface, and…
PITFALL D efinition — The area adjacent to the gestational sac where intermediate trophoblasts and fibrinoid can be found permeating the decidua. Clinical Features Epidemiology Normal structure. You’re Reading a Preview Become a Clinical Tree membership for Full access and…
D efinition — The membranous sac that envelops the developing embryo. Clinical Features Epidemiology The gestational sac can be identified in the majority of samples from previable pregnancies. The gestational sac confirms an intrauterine pregnancy, even in cases in which…