D efinition —An uncommon, nonmetastasizing (usually!) but locally destructive carcinoma of basal keratinocytes with characteristic peripheral nuclear palisading. Clinical Features Epidemiology Rare. Not human papillomavirus (HPV) associated. Elderly women in their 70s and 80s. You’re Reading a Preview Become a…
PITFALL D efinition —A neoplastic proliferation of keratinocytes arising in follicular epithelium. Clinical Features Epidemiology Typically occurs in the middle aged to elderly. Suspected causes include ultraviolet light, immunosuppression, genetic alterations, chemical exposure, viruses, and trauma. You’re Reading a Preview…
PITFALL D efinition —A reactive condition marked by acanthosis and irregular epithelial architecture. Clinical Features Epidemiology Noncontributory. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member.…
PITFALL D efinition —A papillosquamous lesion of significant size, histologically indistinguishable from generic condyloma. Clinical Features Epidemiology A rare entity that most commonly affects young men. Seen more commonly in immunosuppressed patients (human immunodeficiency virus [HIV] positive). Can also be…
D efinition —A papillary exophytic squamous lesion similar in morphology to vulvar intraepithelial neoplasia (VIN) III but with risk of underlying invasion. Clinical Features Epidemiology Identical to that of a classic or usual high-grade VIN. May be associated with an…
D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Exhibits a distinct histology and invasive pattern that is nonmetastasizing. Clinical Features Epidemiology Typically affects women in their seventh and eighth decades and is usually found associated with inflammatory…
D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Human papillomavirus (HPV) negative. Clinical Features Epidemiology Typically affects women in their seventh and eighth decades and is usually found associated with inflammatory dermatosis (differentiated vulvar intraepithelial neoplasia [VIN]).…
D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Comprise tumors associated with classic vulvar intraepithelial neoplasia (VIN). Clinical Features Epidemiology Typically affects women in their sixth decade but can be seen in women under 40 who are…
D efinition —Invasion less than 2 cm in diameter and to a depth of less than 1 mm below the highest epithelial–stromal interface. Epidemiology A wide age range, from second to eighth decade, predominating in the fifth and sixth decades. Patients typically…
D efinition —Vulvar acanthosis with altered differentiation (VAAD) is defined as vulvar acanthosis with variable verruciform architecture that lacks the nuclear atypia characteristic of vulvar intraepithelial neoplasia (VIN) but exhibits abnormalities in keratinocyte differentiation. It is classed as a risk…