D efinition —A benign, nonrecurring spindle cell lesion of the vulvovaginal region, characterized by alternating hypercellular and hypocellular areas. Clinical Features Epidemiology Reproductive-age women. Uncommon. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
D efinition —A highly malignant tumor of dermal melanocytes. Clinical Features Epidemiology Rare. Accounts for approximately 3% of all melanomas in women. The second most common vulvar malignancy. Most often in patients in their sixth decade of life. May be…
D efinition —A melanocytic proliferation with architectural, cytologic, and clinical features that are intermediate between those seen in common nevi and melanoma. Clinical Features Epidemiology Patients have a higher risk of melanoma. Patients with first-degree relatives who have melanoma have…
D efinition —A melanocytic proliferation seen in locations with redundant skin, characterized by large junctional melanocyte nests and transepidermal elimination of nests. Clinical Features Epidemiology Uncommon; estimated prevalence of 2.3% in women. Young women, most often in the third decade…
D efinition —Benign pigmented lesion of mucosal surfaces. Clinical Features Epidemiology No distinct demographic associations. Increased numbers may be seen in Carney complex. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…
D efinition —Secondary involvement of the vulva by metastatic carcinoma. Clinical Features Epidemiology Rare. Accounts for 5% to 8% of vulvar malignancies. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…
D efinition —“Ectopic,” colonic-type neoplasia (adenoma/carcinoma) arising in the vaginal or vulvar mucosa. Clinical Features Epidemiology Origin is in colonic-type epithelium, presumably incorporated into the vaginal or vulvar region following formation of the urorectal septum in early development. Another possible…
D efinition —A malignant mucocutaneous neuroendocrine neoplasm. Clinical Features Epidemiology Very rare (~12 per year in the United States). Vulvar tumors account for about 3% of all Merkel cell carcinomas. Risk factors include age (>60 years) and sun exposure. You’re…
D efinition —Infiltration of the squamous epithelium by mucin-producing neoplastic cells. Clinical Features Epidemiology Uncommon; represents only 1% to 2% of vulvar malignancies. The average age at presentation is 65 years; the majority of patients are over 50 years. You’re…
D efinition —An aggressive variant of squamous cell carcinoma with conspicuous glandular differentiation. Clinical Features Epidemiology Uncommon. Mean age at diagnosis is 65 to 70 years. Associated with chronic vulvar inflammatory disease. Human papillomavirus (HPV) link is unclear but likely…