D efinition —Immature metaplastic or reserve cell proliferations with mild atypia and strong p16 immunostaining. Clinical Features Epidemiology Reproductive-age women. Inconsistent human papillomavirus (HPV) association. Typically present with atypical squamous cells of undetermined significance (ASCUS) cervical smear. You’re Reading a…
D efinition —Any one of the spectrum of alterations within the cervical epithelium of postmenopausal women, including squamous intraepithelial lesions (SILs). Clinical Features Epidemiology Occurs predominantly in postmenopausal women. Also can be seen in any low-estrogen state (postpartum, breast-feeding). You’re…
D efinition —The presence of two different human papillomavirus (HPV)–type specific lesions in the same specimen. Clinical Features Epidemiology Reproductive-age, sexually active women, in the vulva or anal region may be associated with immunosuppression but not specific for this condition.…
D efinition —Immature condyloma represents an infection of the immature metaplastic cervical transformation zone epithelium by human papillomavirus (HPV) type 6 or 11. Also variably called squamous papilloma or papillary immature metaplasia; the most appropriate term is low-grade squamous intraepithelial…
PITFALL D efinition —A variant of condyloma that presents as a grossly enlarged mass and appears to replace or cover the cervix and/or distal vagina. Clinical Features Epidemiology Sexually active, reproductive-age women. Uncommon. You’re Reading a Preview Become a Clinical…
D efinition and T erminology A precancerous lesion arising at the cervical squamocolumnar (SC) junction that displays near full-thickness atypia and variable maturation of the neoplastic epithelium. Should be associated always with high-risk human papillomaviruses (HPVs) and with HPV16 in…
D efinition —An infection of the mature ectocervical and/or metaplastic cervical transformation zone epithelium by human papillomavirus (HPV). Clinical Features Epidemiology Most commonly seen in sexually active, reproductive-age women. Can be diagnosed in any age group. Flat low-grade squamous intraepithelial…
D efinition and T erminology An exophytic cervical condyloma represents an infection of the mature ectocervical or metaplastic cervical transformation zone epithelium by human papillomavirus (HPV) type 6 or 11 (low–cancer-risk subtypes). The most appropriate term is low-grade squamous intraepithelial…
D efinition —A malignancy of skeletal muscle presenting as a polypoid vaginal mass in young girls. Clinical Features Epidemiology Uncommon. Usually seen in females under the age of 5 years. You’re Reading a Preview Become a Clinical Tree membership for…
PITFALL D efinition —A benign vaginal tumor composed of keratin-positive stromal cells. Clinical Features Epidemiology Uncommon. Seen in a wide age range (20 to 80 years), with a mean age of 40 years. You’re Reading a Preview Become a Clinical…