Tag Amit Prabhakar

Red Yeast Rice (Cholestin)

Uses Chinese traditional medicine for therapy of pts with cardiovascular diseases Hypercholesterolemia Prevention of coronary events, stroke, and TIA Treatment of dyslipidemia in statin-intolerant pts Prostate and colon cancer Possible diabetes treatment Perioperative Risks Obtain adequate Hx to determine indication…

Garlic (Allium sativum)

Uses Administered orally and topically as a powder, oil, tablet, and raw clove. Allicin is the pharmacologically active component. Potentially beneficial to the CV system as an antihyperlipidemic (conflicting results in recent clinical trials); also useful as an antimicrobial (…

Glucocorticoids

Uses Used to treat a wide range of illnesses including but not limited to autoimmune disorders, postop nausea and vomiting, and chronic pain Overview/Pharmacology Adrenal cortex produces and releases two different types of corticosteroids: Mineralocorticoids (maintain salt and fluid balance)…

Multiple Myeloma

Risk Represents 1.6% of all new cancer cases in USA; estimated 26,850 new cases in 2015. Estimated 11,240 deaths, or 1.9% of all cancer deaths in USA in 2015. Incidence: 7.5:100,000 white males; 4.5:100,000 white females; 15.1:100,000 black males; 11.2:100,000…

Hypopituitarism

Risk Incidence: 45.5:100,000. 30% of pituitary macroadenomas (>10 mm) cause one or more hormone deficiencies. About 4.2 years after pituitary radiation therapy, some 50% of pts have hypopituitarism. Less common causes include empty sella syndrome, head trauma, infiltrative disease, and…

Hypernatremia

Risk Older age, infants, prior brain injury, DM, surgery, diuretic therapy, altered mental status, insufficient water intake, DI, hypertonic sodium solution (including sodium bicarbonate), hyperalimentation, hyperaldosteronism, Cushing syndrome, and hypothalamic injury Perioperative Risks Increased incidence of morbidity and mortality, seizures,…

Herpes, Type II

Risk Incidence within USA of HSV-2 is estimated at 40–60 million (20% of sexually active adults). Approximately 536 million people (16% of population) infected worldwide, most unaware of the disease. Highest prevalence in women, African Americans, and lower socioeconomic groups.…

Gout

Risk Overall incidence: 0.05% in the USA population Most common inflammatory joint disease among men Associated with nephropathy, most commonly nephrolithiasis (10–40% of pts) Also associated with CV disease, specifically an increased risk of myocardial infarction, but also including heart…

Alagille Syndrome

Risk Also known as syndromic bile duct paucity Affects cardiac, musculoskeletal, ocular, facial, and neurodevelopmental systems Most common inherited disorder that causes chronic liver disease in children 1:100,000 births with equal gender incidence Perioperative Risks Cardiac congenital anomaly and hemodynamic…

Acidosis, Renal Tubular

Risk Incidence in USA: Unknown Present in a variety of disease states, from mild to severe systemic illness Perioperative Risks Hemodynamic instability (related to arteriolar vasodilation, acidosis, and decreased cardiac output) Hyperkalemia Insulin resistance and hyperglycemia Acute respiratory failure Worry…