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Incidence in USA: 3 million; 350 million in world
Race with highest prevalence: African Americans
Increased risk of complications following CABG.
Periop mortality rate in published cases of SA trait is 0.8%.
Some increased risk of CVA and pulm infection but not well quantified.
Increased risk of vasoocclusive phenomenon with hypoxia and stress.
Sudden death with stresses such as vigorous exercise make one worry because recovery from surgery may be considered a similar stress as vigorous exercise.
Is not a disease
Is not a cause of abnormalities in blood count
Does not produce vaso-occlusive symptoms under physiologic conditions; painful crisis not a hallmark or concomitant of condition
Does not adversely affect individual’s life expectancy
Dx established by Hgb electrophoresis
See also Sickle Cell Disease
Heterozygous, in which individual has one beta S and beta A globin gene (SA disease); Sickle Thal is one beta S and one beta C (SC disease)
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