Propyphenazone

General information

Propyphenazone is a pyrazolone derivative that has been incorporated into many over-the-counter analgesic combinations in many countries. There is no evidence that it causes fewer adverse reactions than phenazone (antipyrine), as was originally supposed, since neither compound has been widely studied alone.

In a systematic review of comparisons of Saridon (propyphenazone 150 mg + paracetamol 250 mg + caffeine 50 mg), paracetamol 500 mg + aspirin 500 mg + ibuprofen 200 mg, and placebo in 500 healthy adults, of whom 329 (66%) had moderate and 171 (34%) severe acute dentoalveolar pain, more of the patients who received Saridon reported “pain gone/partly gone” and fewer reported “pain unchanged or worse” at 30 and 60 minutes [ ]. There were adverse events in 20 patients (4.0%), with no significant differences between the groups. The most common adverse events were gastrointestinal disorders, followed by nervous system, skin, subcutaneous tissue, respiratory, cardiac, and general disorders.

Organs and systems