Propylhexedrine

General information

Propylhexedrine is a cycloalkylamine that is structurally similar to metamfetamine and causes release of dopamine, noradrenaline, and 5HT from presynaptic vesicles. However, its effects on the brain require high doses and its main action is as an α- and β-adrenoceptor agonist, causing vasoconstriction. It has been used to treat obesity [ ] and in the form of the volatile base is used in nasal inhalers in the treatment of nasal congestion [ ]; it is also a component of some liquid decongestant mixtures. When inhaled, and especially if over-used, it can cause nasal irritation, rebound congestion, and chronic rhinitis.