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Procyclidine
See also Anticholinergic drugs
General information
Procyclidine is an anticholinergic drug [ ]. The usual oral dose, 20–30 mg/day, is likely to produce only mild anticholinergic adverse reactions, but involuntary movements, with chewing and sucking, have been described in some patients [ ]. Even small doses have produced toxic confusional states when procyclidine was combined with phenothiazines for schizophrenia. Procyclidine is more likely to produce sedation than stimulation.
Organs and systems
Nervous system
During treatment of metoclopramide-induced neuroleptic malignant syndrome with high-dose intravenous procyclidine, which temporarily reduced the muscle rigidity and reversed most of the autonomic features, there was a paradoxical reduction in heart rate and an increase in bowel movements, typical of a cholinergic rather than an anticholinergic action [ ].
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