Postpubertal-type yolk sac tumor


  • Germ cell tumor (GCT) in the postpubertal testis composed of malignant epithelial cells recapitulating the extraembryonic structures, such as the yolk sac, allantois, and extraembryonic mesenchyma; also called endodermal sinus tumor

Clinical features


  • Patients are typically 15–40 years old.

  • Usually as a component of mixed GCTs in postpubertal children and adults, present in 44% of non-seminomatous GCTs.

  • The pure form is extremely rare in this age group, accounting for less than 1% of testicular GCTs.

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