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Pain is the chief complaint in many patients. Although pain may arise from a variety of nonneurologic causes, this chapter will cover the diagnosis and management of six pain syndromes that are uniquely neurologic. Headache is covered in Chapter 15 . Treatment of pain, independent of the underlying cause, is usually possible with appropriate therapeutic agents, but rational management decisions can be made only after identification of the site of the pain-producing lesion and recognition of the pathophysiology of the particular pain syndrome. Pain can be either acute or chronic in which nociceptor and spinothalamic sensitization may contribute to the development of chronic pain. Fig. 18.1 outlines the possible sites and mechanisms of pain. This chapter will address the following pain syndromes:
Complex regional pain syndrome (CRPS; reflex sympathetic dystrophy, causalgia, sympathetically maintained pain [SMP])
Facial pain (trigeminal neuralgia)
Postherpetic neuralgia
Peripheral neuropathy
Cervical or lumbar radiculopathy
Brachial plexopathy/neuritis
Questions to be asked at the time of initial contact depend on the pain syndrome. Localization will determine the subsequent path of questioning, but certain questions are pertinent to all pain syndromes. The first three questions can be asked over the phone to prepare for the history taking and examination.
Where is the pain?
Is the pain localized or diffuse? Does it correspond to a particular anatomic pattern or dermatomal distribution? Does it radiate?
When did it begin?
Did it come on suddenly or worsen over time?
Is there a history of injury, underlying neurologic disease, or other chronic medical condition?
Acute injury from lifting or from a mechanical task is common for radicular pain. Traumatic injury to a limb may precede CRPS. A variety of underlying medical conditions predispose to painful peripheral neuropathies, including diabetes mellitus, alcoholism, and a variety of medications.
Are there red flags?
Is there acute and significant weakness or sensory loss? Is there a change in normal bowel or bladder function? Does the patient have a fever or unintentional weight loss? Is there a known history of cancer or other immunocompromised condition?
No orders should be given over the phone. Although analgesia may be required to obtain an adequate history and perform an adequate physical examination, it is best to evaluate the patient yourself first.
“Will arrive at the bedside as soon as possible.”
What is the differential diagnosis based on the location of pain?
Face: trigeminal neuralgia (tic douloureux), herpes zoster (ophthalmicus or oticus), temporomandibular joint disease, atypical facial pain, carotid artery dissection, cavernous sinus thrombosis
Neck: rheumatoid arthritis, osteoarthritis/spondylosis, discogenic pain, meningitis, subarachnoid hemorrhage, vertebral artery dissection, carotid artery dissection, tumor/mass, tension headache, myofascial pain
Low back: herniated nucleus pulposus, epidural abscess, vertebral metastasis, osteomyelitis, osteoarthritis/spondylosis, discitis, herpes zoster, musculoligamentous strain, ankylosing spondylitis, retroperitoneal disease (referred pain from neoplasm, pancreatitis, ulcer, aortic aneurysm, etc.), kidney stone, pyelonephritis, compression fracture, sacroiliac (SI) joint
Arms/shoulders: cervical radiculopathy, brachial plexitis, ischemic heart disease, entrapment syndromes (suprascapular syndrome, radial nerve entrapment, interosseous syndrome) musculoskeletal pain (intraarticular pathology, bursitis, tendinosis, fracture), CRPS
Legs/hips: osteoarthritis, diabetic amyotrophy, lumbar radiculopathy, polyradiculopathy (cytomegalovirus [CMV], neoplastic), spinal stenosis, lumbar plexopathy, musculoskeletal pain (intraarticular pathology, bursitis, tendinosis, fracture)
Hands/feet (e.g., painful peripheral neuropathies): acquired peripheral neuropathy (diabetes mellitus, alcoholism, HIV/AIDS, paraproteinemia/myeloma toxin exposure, amyloidosis, paraneoplastic), mononeuritis multiplex, carpal tunnel syndrome, inherited neuropathies (Fabry disease, Tangier disease, dominantly inherited sensory neuropathy), CRPS, musculoskeletal pain (intraarticular pathology, bursitis, tendinosis, fracture), erythromelalgia
Neck pain is one category in which a missed early diagnosis could lead to significant disability or death. Etiology of pain syndromes in this category includes carotid artery dissection, meningitis, and subarachnoid hemorrhage.
Low back pain can also be a harbinger of a more threatening diagnosis, which may lead to permanent disability such as an epidural abscess, hematoma, or mass lesion.
Does the patient appear acutely ill?
Tachypnea, diaphoresis, or a decreased level of alertness suggests that the medical illness should be attended to before the pain syndrome is addressed.
How severe does the pain appear to be?
Pain is very subjective, and tolerance can vary; one should ask about severity and observe the patient’s pain behaviors.
Fever suggests infection. Tachypnea may mean an underling medical condition or hyperventilation in response to pain. Tachycardia and elevated blood pressure often accompany acute pain.
Define the character of the pain.
The questions posed during the phone call should be asked directly (Where is the pain? When did the pain begin?). One strategy is to differentiate between neuropathic and somatic pain. Neuropathic pain is often described as burning, sharp, or shooting. Neuropathic pain may be induced by normally innocuous stimuli such as the touch of a shirt or spray from a shower (dysesthesia, allodynia). Somatic pain is oftentimes described as dull or achy. You should also ask about the presence of radiating pain.
What makes the pain better or worse?
Ask if certain positions lessen or worsen pain. For example, an acute herniated lumbar disk is often worse with lumbar flexion, whereas peripheral neuropathy can be most bothersome at rest.
What is the patient’s medical history?
Ask about specific conditions (such as diabetes) and exposures to neurotoxic substances (such as chemotherapy or alcohol) when considering a diagnosis of peripheral neuropathy. Any history of trauma may lead to a diagnosis of nerve or root compression or CRPS. Malignancy may produce neural pain either by compression from a mass or by neural infiltration. A previous stroke, particularly in the thalamus, the lateral medulla, or the parietal lobe, may produce a central pain syndrome.
What medications has the patient tried already?
Musculoskeletal: If there is pain in or around a joint, look for signs of inflammation, palpate for tenderness, and test the joint for active and passive range of motion. Be sure to percuss the spine to check for osseous lesions such as fractures, infection, or neoplastic disease. A straight leg raise test should be done when there is low back or leg pain ( Fig. 18.2 ).
Skin: Rash may accompany an infection or a drug reaction. Vesicles of herpes zoster may precede or follow the associated neuralgia. Peripheral neuropathy and CRPS can cause hair loss and trophic changes.
Abdomen: Hepatomegaly may suggest chronic alcohol abuse. Abdominal or pelvic masses may produce pain that is referred to the back or the legs.
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