Resuscitative Endovascular Balloon Occlusion of the Aorta

Must-Know Essentials: Resuscitative Endovascular Balloon Occlusion of the Aorta in Abdominal Trauma (Blunt/Penetrating) Background ■ For resuscitative endovascular balloon occlusion of the aorta (REBOA), an endovascular balloon is placed in the aorta to control hemorrhage, as well as to maintain myocardial and cerebral perfusion in traumatic arrest and hemorrhagic shock by augmenting afterload. Zones of Aorta for Reboa Placement ■ Average diameter of the aorta ■…

Principles of Management of Hemorrhagic Shock

Algorithm: Management of hemorrhagic shock Open full size image Must-Know Essentials: Principles of Management of Hemorrhagic Shock Control of Airway and Ventilation ■ Supplemental oxygen ■ Definitive airway ■ Endotracheal intubation/surgical airway ■ Ventilatory support Access for Fluid Resuscitation ■ Peripheral line ■ Antecubital peripheral line ■ Two large-caliber (14–16 gauge) catheters ■ Short, large-caliber peripheral IV lines are preferred for rapid infusion of large volumes…

Assessment of Shock in Trauma Patients

Algorithm: Assessment of shock in trauma patients Open full size image Must-Know Essentials: Shock in Trauma Patients Classification of Shock in Trauma Patients ■ Hemorrhagic shock: most common in trauma patients ■ Bleeding from lacerations ■ Bleeding in the soft tissue of the extremity injuries ■ Fractures: due to bleeding at fracture sites ■ Pelvic fractures: 2000–3000 mL ■ Femur shaft fracture: 1000–1500 mL ■ Tibia…

Management of Breathing and Ventilation

Algorithm: Compromised breathing and ventilation Open full size image Must-Know Essentials: Causes of Compromised Breathing and Ventilation Emergent Concern of Breathing and Ventilation ■ Complex maxillofacial trauma ■ Midface fractures ■ Bilateral mandibular body fracture ■ Severe brain injury (GCS score <8), leading to decreased central respiratory drive ■ Comatose patients ■ Hemorrhagic shock ■ High cervical spine injury ■ High cervical cord injury at C3/4…

Airway Assessment and Management

Algorithm: Assessment and Management of Airway Open full size image Must-Know Essentials: Assessment of Compromised Airway Manifestations of Compromised Airway ■ Patient unable to verbalize ■ Noisy breathing ■ Stridor ■ Patient using or retracting accessary muscles of breathing ■ Agitation ■ Central nervous depression ■ Tachypnea ■ Cyanosis ■ Low oxygen saturation Must-Know Essentials: Definitive Airway Definition of Definitive Airway ■ A tube in the…

The Vicious Cycle of Trauma

The vicious cycle of trauma and the lethal triad Open full size image Must-Know Essentials: The Vicious Cycle of Trauma and the Lethal Triad Definition ■ Vicious cycle of trauma ■ Hemorrhage after trauma initiates a cycle of acidosis, hypothermia, and coagulopathy that leads to continued bleeding with eventual death. ■ Lethal triad ■ A combination of hypothermia, acidosis, and coagulopathy ■ Associated with very high…

Process of Evaluation of Trauma Patients

Algorithm: Evaluation of trauma patients (ATLS guidelines) Open full size image Must-Know Essentials: Process of Evaluation of Trauma Patients Primary Survey (A, B, C, D, E) and Resuscitation ■ A: Airway and cervical spine protection ■ B: Breathing and ventilation ■ C: Circulation and control of hemorrhage ■ D: Disability: Neurological status ■ E: Exposure and environmental protection Secondary Survey ■ After primary survey and management…

Death in Trauma Patients

Trimodal distribution of deaths in trauma patients Open full size image Must-Know Essentials: Death in Trauma Patients You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

Current Clinical Status of the Extracorporeal Liver Support Devices

The liver is a vital organ with more than 500 functions, including protein synthesis, detoxification, regulation, metabolic functions, and biliary production. Liver failure, whether occurring without preexisting liver disease (acute liver failure [ALF]) or as an acute decompensation of a chronic liver disease (acute-on-chronic liver failure [ACLF]), is characterized by a sudden deterioration of the liver function leading to accumulation of toxins and reduction of protein…

Extracorporeal Perfusion for Resuscitation of Marginal Grafts

Principles of Organ Preservation and Machine Perfusion Interrupting the blood flow to an organ is an unavoidable step in the transplantation process. Even when the procedures in the donor and the recipient are perfectly coordinated, a period of ischemia necessarily transpires. As the supply of metabolic substrates declines, adenosine triphosphate (ATP) is depleted, sodium accumulates intracellularly, and the transmembrane electrochemical gradient is lost. Cell swelling ensues,…

Ischemia-Reperfusion Injury in Liver Transplantation

Liver transplantation is the standard of care in patients with end-stage liver disease and those with tumors of hepatic origin. In 2011 there were 16,107 patients in the United States waiting for a liver transplant, but only 6341 transplants were performed, implying a shortage of about 10,000 donor livers to meet the need. During the same time 1589 patients died while awaiting a transplant, whereas 1349…

Stem Cells and Liver Regeneration

The liver has an amazing regenerative capacity, which can especially be observed in response to toxic injury and infection. However, in patients with certain hepatic conditions such as cirrhosis, steatosis, and conditions due to age—where liver matrix and cells are compromised—liver regeneration is impaired. In these conditions, where the architecture of the organ is altered, it is still unclear which cellular and molecular pathways prevent regeneration.…

Liver and Hepatocyte Xenotransplantation

A severe shortage of human livers for allotransplantation has sparked interest over the years in the potential use of animals in lieu of humans as a source of livers—that is, xenotransplantation. Besides offering a plentiful supply of livers, xenotransplantation might offer a transplant inured to hepatitis C. Xenogeneic livers can also be used for extracorporeal “xenoperfusion,” for devices containing xenogeneic hepatocytes, auxiliary liver transplants, bridge liver…

Genetic and Genomic Potential in Liver Transplantation

In 1953 Watson and Crick published in Nature the double helix structure of DNA. The following year Joseph Murray performed the first successful human kidney transplant on identical twins, which was published 2 years later in the Journal of the American Medical Association . The subsequent 50 years following these seminal achievements has seen an explosion in our understanding of the basic immunological processes involved in…

Survival and Quality of Life in Children

Human liver transplantation was first attempted in 1963 in a child with biliary cirrhosis resulting from extrahepatic biliary atresia. At the time such patients were considered to be the best candidates for liver transplantation because there were no other options to treat such children with terminal liver disease. As the outcomes improved following the introduction of cyclosporine in 1980, the diagnostic indications for liver transplantation in…

Long-Term Functional Recovery and Quality of Life

In 1983, after review of over 500 cases, the National Institutes of Health issued a consensus statement establishing liver transplantation (LT) as an effective and durable therapy for adults and children with end-stage liver disease. Before this event the procedure was largely viewed as an experimental, last-ditch effort to save critically ill patients who had marginal chances for short-term survival, much less opportunities to carry out…

U.S. Trends in Transplantation

The success and evolution of liver transplantation as a therapeutic treatment for patients with advanced liver disease led to a National Institutes of Health–sponsored Consensus Development Conference, which recommended that a “registry or clearinghouse be established for collection and evaluation of all available data on liver transplantation.” The National Institute of Diabetes and Digestive and Kidney Diseases–sponsored Liver Transplantation Database was subsequently established in 1985 for…

Outcome Predictors in Transplantation

Orthotopic liver transplantation (OLT) is a durable and the definitive lifesaving treatment modality for patients suffering from irreversible liver failure. Although thousands of patients receive liver transplants each year, the limited organ supply remains a reality, and many patients are not as fortunate. Since 1987 the rate of new registration for the United Network for Organ Sharing (UNOS) liver waiting list has far exceeded the growth…

Long-Term Toxicity of Immunosuppressive Therapy

The continued success of liver transplantation over the past quarter century can be attributed to a number of factors: better understanding of disease pathophysiology, enhanced intraoperative management, and improved posttransplantation care, to name a few. Atop this list, however, is the introduction of new immunosuppressive agents, all of which have contributed to improved graft and patient survival. Like any medication, these agents are not without side…