Late Responses

Nerve conduction studies are most often used to assess distal nerve segments, with routine stimulation seldom done above the elbow or knee. Few studies can be easily performed to assess the more proximal nerve segments (plexus and roots). In the arm, surface stimulation can be performed proximally in the axilla and at Erb’s point, although technical factors limit these studies, especially at Erb’s point. Needle stimulation…

Basic Nerve Conduction Studies

After the history is taken and a directed physical examination is performed, every study begins with nerve conduction studies (NCSs). The needle electromyography (EMG) examination is performed after the NCSs are completed because the findings on the NCSs are used in the planning and interpretation of the needle EMG examination that follows. Peripheral nerves usually can be easily stimulated and brought to action potential with a…

Anatomy and Neurophysiology for Electrodiagnostic Studies

The electromyographer need not have detailed knowledge of all the electrical and chemical events that occur at a molecular level to perform an electrodiagnostic (EDX) study. However, one must have a basic understanding of anatomy and physiology to plan, perform, and properly interpret an EDX study. In the everyday evaluation of patients with neuromuscular disorders, nerve conduction studies (NCSs) and electromyography (EMG) serve primarily as extensions…

Approach to Nerve Conduction Studies, Electromyography, and Neuromuscular Ultrasound

Electrodiagnostic (EDX) studies play a key role in the evaluation of patients with neuromuscular disorders. In selected cases, the additional use of neuromuscular ultrasound (U/S) can add key complementary anatomical and diagnostic information. EDX studies include nerve conduction studies (NCSs), repetitive nerve stimulation, late responses, blink reflexes, and needle electromyography (EMG), in addition to a variety of other specialized examinations. NCSs and needle EMG form the…

Recommended resources and sites for the neuroscience of spinal cord injury

List of Abbreviation SCI Spinal cord injury Acknowledgements (in alphabetical order) We would like to thank the following authors for contributing to the development of this resource. We apologize if some suggested material was not included in this chapter or has been moved to different sections. Abou L, Aftab K, Alam M, Bernabéu-Sanz A, Breshnan J, Calderón Vallejo D, Champs A, Cunha do Espírito Santo, C…

Support in spinal cord injury: A focus on robotics

List of abbreviations ADL activity of daily living AIS ASIA impairment scale ARTIC advance robotic therapy integrated centers ASIA American Spinal Injury Association CNS central nervous system CPG central pattern generator FES functional electrical stimulation SCI spinal cord injury Introduction The incorporation of robotics in the field of neurorehabilitation is taking place rapidly, both in research and in its clinical applications, and is presented as a…

Biomaterials, spinal cord injury, and rehabilitation: A new narrative

List of abbreviations AEMA 2-aminoethyl methacrylate BBB Basso, Beattie, Bresnahan score BDNF brain-derived neutrophic factor BSCB blood–spinal cord barrier CNS central nervous system ECM extracellular matrix HA hyaluronic acid HP hydroxyphenyl MOEAA [2-(methacryloyloxy)ethoxy]acetic acid MOETA + [2-(methacryloyloxy)ethyl]trimethylammonium chloride MSCs mesenchymal stem cells NFs nanofibers NPs nanoparticles NTs nanotubes NT-3 neurotrophin-3 NWs nanowires PCL poly(ɛ-caprolactone) PEG polyethylene glycol PEI polyethyleneimine PHEMA poly(2-hydroxyethyl methacrylate) PHPMA poly(N-(2-hydroxypropyl)-methacrylamide) PLA polylactic…

Mobile health apps and self-management for spinal cord injury rehabilitation

Abbreviations SCI spinal cord injury mHealth mobile health eHealth electronic health PA physical activity SUS system usability scale Introduction For individuals living with spinal cord injury (SCI), inadequate health management can result in adverse psychological and physical health outcomes including autonomic dysreflexia, pressure sores, bowel and bladder dysfunction, depression, and spasticity ( ). Learning to self-manage health, i.e., symptoms, treatment, and lifestyle changes inherent to living…

Community-based activity-based therapy for spinal cord injuries rehabilitation

Abbreviations SCI spinal cord injury ABT activity-based therapy CPGs central pattern generators LT locomotor training ISNCSCI International Standards for Neurological Classification of Spinal Cord Injuries ICF International Classification of Functioning, Disability and Health FES functional electrical stimulation NMES neuromuscular electrical stimulation BWSTT body weight support treadmill training WBV whole body vibration Introduction Injuries to the spinal cord result in profound disability and involve many body systems,…

Rehabilitation in spinal cord injury: Exercise and testing for cardiorespiratory endurance and musculoskeletal fitness

Abbreviations SCI spinal cord injury PwSCI persons with a spinal cord injury VO 2peak peak volume of oxygen consumption VO 2max maximal volume of oxygen consumption ACE arm crank ergometer 1-RM one repetition maximum WMS WheelMill System 6-MAT 6-minute arm test 6MPT 6-minute push test RPE rate of perceived exertion ASIA The American Spinal Injury Association Impairment Scale PO power output W watts RM repetition maximum…

Spinal cord injury rehabilitation: Linking service delivery and community integration

Abbreviations AR active rehabilitation ICF International Classification of Functioning Disability and Health SCI spinal cord injury TR transitional rehabilitation UNCRPD United Nations Convention on the Rights of Persons with Disabilities VR vocational rehabilitation Introduction Community integration includes having access to appropriate housing, being able to mobilize in the community, being able to participate in work, leisure or educational activities of choice, and engaging in satisfying social…

Spinal cord injury: Multiple family group (MFG) education and support

Introduction Damage to the spinal cord can be a life-changing event, usually occurring suddenly as a result of an accident, and presenting both acute and long-term medical effects to individuals and their families. Because these events usually happen unexpectedly, suddenly the individual is thrown into the chaos of the health care system. Rarely do people have any idea of the implications on future health, lifestyle, or…

Trophic factors in patients with spinal cord injury

Abbreviations BDNF brain-derived neurotrophic factor CNTF ciliary neurotrophic factor ES electrical stimulations FES functional electrical stimulation FGF fibroblast growth factors GDNF glial-derived neurotrophic factor GH growth hormone GnRH gonadotropin-releasing hormone IGF-1 insulin-like growth factor-1 iPSCs induced pluripotent stem cells MSCs mesenchymal stem cells NGF nerve growth factor NPCs neural progenitor cells NT3 neurotrophin 3 NT4/5 neurotrophin 4/5 OECs olfactory cells OPCs oligodendrocyte progenitor cells SCI spinal…

Corticospinal tract regeneration after spinal cord injury: Implications for treatment and recovery

Abbreviations A adult C cervical ChABC chondroitinase ABC CNS central nervous system CSPG chondroitin sulfate proteoglycans CST corticospinal tract E embryonic Htt huntingtin gene KLF Krüppel-like factor MSE motor synergy encoder mTOR mammalian target of rapamycin NgR Nogo-A receptor NPC neural progenitor cell NT-3 neurotrophine-3 P post-natal PTEN tumor suppressor phosphatase and tensin homolog SCI spinal cord injury SOCS3 suppressor of cytokine signaling 3 T thoracic…

Vitamin D and spinal cord injury

Abbreviations 25(OH)D 25-hydroxyvitamin D, also known as calcidiol 1,25(OH) 2 D 1,25-dihydroxyvitamin D, also known as calcitriol IOM Institute of Medicine UVB ultraviolet B SCI spinal cord injury VDR vitamin D receptor Introduction Based on data collected from the National Health and Nutrition Examination Survey (NHANES), the prevalence of vitamin D deficiency (< 50 nmol/L) in the United States is estimated to be 39.9% ( ).…

Use of (−)-epigallocatechin-3-gallate on spinal cord injury

List of abbreviations AGEs advanced glycation end products AD Alzheimer’s disease ACR acrylamide AKT protein kinase B APP amyloid precursor protein AQP4 astrocyte expressing aquaporin-4 ARE antioxidant response element α7nAChR alpha-7 nicotinic acetylcholine receptor BBB blood-brain barrier Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 BDNF brain-derived neurotrophic factor CAT catalase COX-2 cyclooxygenase-2 EGCG (−)-epigallocatechin-3-gallate eNOS endothelial nitric oxide synthase FASN fatty acid synthase FGF2 fibroblast…

Curcumin usage for inflammation and spinal cord injury

List of abbreviations AGP α1-acid glycoprotein AMPK adenosine monophosphate-activated protein kinase AQP4 aquaporin 4 BBB Basso, Beattie, Bresnahan ERKs extracellular signal-regulated kinases GFAP glial fibrillary acidic protein GSK-3β glycogen synthase kinase 3 beta HO-1 hemeoxygenase 1 ICE interleukin 1β converting enzyme IL interleukin IP intraperitoneal JAK-STAT Janus kinase—signal transducer and activator of transcription MAPK p38 mitogen-activated protein kinase MDA malondialdehyde MD-2 myeloid differentiation protein 2 NF-H…

Viral vector gene therapy approaches for regeneration and repair in spinal cord injury

List of abbreviations SCI spinal cord injury CNS central nervous system AdV adenovirus HSV herpes simplex virus LV lentivirus AAV adeno-associated virus IM intramuscular IN intraneural IV intravenous IT intrathecal NGF nerve growth factor BDNF brain-derived neurotrophic factor NT neurotrophin BBB blood-brain barrier CSPG chondroitin sulfate proteoglycan ChABC chondroitinase ABC ADAMTS4 a disintegrin and metalloproteinase with thrombospondin motifs 4 Introduction Traumatic spinal cord injury (SCI) results…

Stem cells and chronic spinal cord injury: Overview

Abbreviations ALS amyotrophic lateral sclerosis BDNF brain-derived neurotrophic factor CNS central nervous system DNA deoxyribonucleic acid EMG electromyography ESC embryonic stem cell GABA gaba-aminobutyric acid iPSC induced-pluripotent stem cell ISNCSCI International standards for neurological classification of spinal cord injury MSC mesenchymal stem cell ROS reactive oxygen species SCI spinal cord injury Acknowledgements None. Funding This work was unfunded. Disclosure statement The authors report no conflict of…

High-intensity interval training in individuals with spinal cord injury

Abbreviations AGREE Appraisal of Guidelines, Research and Evaluation HIIT high-intensity interval training MIT moderate-intensity continuous training NSCISC National Spinal Cord Injury Statistical Center SCI spinal cord injury SIT sprint interval training T2D type 2 diabetes VO 2 max maximal oxygen consumption Introduction This chapter summarizes the public health issue of physical inactivity (i.e., lack of participation in health-enhancing exercise behavior) among people with spinal cord injury…