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Rotaviruses

Before the availability of rotavirus vaccines, rotaviruses were the most common cause of severe infant and childhood gastroenteritis worldwide, responsible for 40% of all diarrheal hospitalizations and more than half a million deaths among children aged <5 years annually. To mitigate this substantial disease burden, rotavirus vaccines were developed and are now licensed in many countries. By 2020, 103 countries had introduced rotavirus vaccines in their…

Coltivirus (Colorado Tick Fever)

Colorado tick fever (CTF) is an acute febrile illness caused by CTF virus, a double-stranded RNA virus in the Coltivirus genus of the family Reoviridae ( Box 215.1 ). , The virus is transmitted to humans through the bite of an infected Rocky Mountain wood tick, Dermacentor andersoni ( Fig. 215.1 ). BOX 215.1 Colorado Tick Fever: Agent and Epidemiology Agent Colorado tick fever virus, Coltivirus…

Human Parvoviruses (Parvovirus B19 and Bocavirus)

Parvoviruses—small (20–25 nm), nonenveloped, icosahedral, single-stranded DNA viruses with a linear genome of between 4500 and 5600 nucleotides—are common infectious agents of animals, including birds and insects, as well as humans. At least five different genera of parvovirus have been detected in humans: bocaparvoviruses, dependoparvoviruses, erythroparvoviruses, protoparvoviruses, and tetraparvoviruses. Human bocavirus (HBoV) has been identified in respiratory secretions of young children with acute wheezing and lower…

Hepatitis B and Hepatitis D Viruses

Hepatitis B Virus Description of the Pathogen Hepatitis B virus (HBV), a member of the Hepadnaviridae family, is an enveloped virus that contains a circular partially double-stranded DNA genome that is 3.2 kb in length. The small genome consists of four overlapping reading frames. , Because the presence of HBV is necessary for infection with the hepatitis delta virus (HDV), both pathogens are discussed in this…

BK, JC, and Other Human Polyomaviruses

Polyomaviruses are a subgroup of small, ubiquitous DNA viruses that belong to the family Papovaviridae. The two most commonly known human polyomaviruses are the BK virus and JC virus, which were first described in 1971. , Subsequently, 12 other human polyomaviruses have been identified. WU polyomavirus and KI polyomavirus in 2007, Merkel cell polyomavirus in 2008, human polyomavirus-6, human polyomavirus-7, and trichodysplasia spinulosa virus in 2010,…

Human Papillomavirus

Papillomaviruses are species specific and widely distributed among mammals and nonmammalian animal species. Human papillomaviruses (HPVs) are strictly epitheliotropic and cause infections and cancer of the skin and mucous membranes. Clinical conditions include anogenital and oral infections and cancers, as well as recurrent respiratory papillomatosis. The Virus And Pathogenesis HPVs are non-enveloped, double-stranded DNA viruses with a small circular genome of approximately 8000 base pairs. HPV…

Adenoviruses

Acknowledgement The author acknowledges substantial contributions of Gail J. Demmler-Harrison to this chapter in previous editions. Adenoviruses are relatively small, nonenveloped double-stranded DNA viruses belonging to the family Adenoviridae (from adenos, the Greek word meaning “gland”). They were first isolated from adenoid tissue, and there are 51 human serotypes, which are defined by biologic characteristics, including immunochemical methods, such as serum neutralization and hemagglutination. The use…

Human Herpesvirus 8 (Kaposi Sarcoma–Associated Herpesvirus)

In 1872, Moritz Kaposi, a Hungarian dermatologist, first described in five men an aggressive, pigmented, multicentric sarcoma of the skin that disseminated to multiple sites. It was rare and received little attention until similar lesions were observed in African children and adults and subsequently were found in association with HIV infection in the 1980s. Although the cause of Kaposi sarcoma (KS) was suspected to be infectious,…

Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)

Epstein-Barr virus (EBV), a ubiquitous herpesvirus of humans, was discovered in 1964. The causal relationship between EBV and infectious mononucleosis (IM) was observed in 1968. The spectrum of associated infections ranges from asymptomatic to self-limited mononucleosis in healthy hosts to progressive infections in patients with acquired or inherited disorders of immunity. Description Of The Pathogen EBV is a γ-herpesvirus. Mature, infectious particles are 150–200 nm in…

Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum)

Human Herpesvirus 6 Human herpesvirus 6 (HHV-6) was first isolated from the peripheral blood lymphocytes of adults with lymphoproliferative diseases and HIV infection and was named human B-lymphotropic virus. When additional isolates were identified in CD4 + lymphocytes, further characterization indicated that the virus was a herpesvirus. Because it was the sixth member of the herpesvirus family, it was renamed Human herpesvirus 6. Two years after…

Cytomegalovirus

Cytomegalovirus (CMV) is a ubiquitous virus that infects most individuals worldwide. In immunocompetent individuals, CMV causes mild to no symptoms but can cause significant disease in immunocompromised patients. Congenital CMV is the most common infection in newborns worldwide and is a leading cause of hearing loss in children. In addition, CMV is an important cause of disease in solid organ and stem cell transplant recipients and…

Varicella-Zoster Virus

Varicella-zoster virus (VZV) is an alphaherpesvirus that is related most closely to herpes simplex viruses 1 and 2. Primary infection with VZV causes varicella, commonly called chickenpox. VZV establishes latent infection in dorsal root and cranial ganglia and can reactivate to cause herpes zoster, often referred to as shingles. The double-stranded DNA genome of the virus encodes >70 proteins, including regulatory and virion structural proteins and…

Herpes Simplex Virus

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) belong to the Alphaherpesvirinae subfamily of herpesviruses. The large DNA viruses have a short reproductive cycle, rapidly produce lytic infection in tissue culture, and remain latent in sensory neural ganglia. After infection of the oral mucosa, usually by HSV-1, the virus becomes latent in the trigeminal ganglia. After genital infection by HSV-2 or HSV-1, the latent…

Introduction to Herpesviridae

The family Herpesviridae contains three subfamilies: Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae. , The eight known human herpesviruses are represented in six genera, which are shown with the typical characteristics of the subfamilies in Table 203.1 . TABLE 203.1 Members of Herpesviridae Family Subfamily Characteristics Genus Member Alphaherpesvirinae Short reproductive cycle Efficient destruction of infected cells with release of viral progeny Rapid spread in culture Latency in sensory…

Poxviridae

Despite the eradication of smallpox as a human pathogen, several poxviruses remain clinically significant, including monkeypox, vaccinia (i.e., virus used for smallpox vaccination), molluscum contagiosum, and several relatively uncommon zoonotic viruses. Concern about smallpox as a bioterrorist weapon also has led to continued interest in poxvirus research. Concurrently, interest in poxviruses (vaccinia virus in particular) as vaccine vectors and potential immunotherapeutic agents has contributed to a…

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Acknowledgements This chapter includes information included by Drs. Gary S. Marshall and Bryan D. Carter in previous editions of the book. It also relies heavily on the collaborative efforts of members of the international writing group for the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Primer, Drs. Rosemary A. Underhill, Kenneth J. Friedman, Alan Gurwitt, Marvin S. Medow, Malcolm S. Schwartz, Nigel Speight, Julian M. Stewart, Rosamund Vallings, and…

Kawasaki Disease

Kawasaki disease (KD) is the most common cause of acquired heart disease in children in the developed world. The epidemiology and clinical features of the illness point to an infectious etiology, but the cause remains unknown. KD is a unique vasculitis that occurs in previously healthy young children and can result in serious long-term coronary artery disease or death. Approximately 20% of children with KD who…

Ureaplasma urealyticum

Microbiology Members of the family Mycoplasmataceae are small pleomorphic bacteria that characteristically lack a cell wall. Shapes range from filamentous to spherical, with diameters up to 0.8 μm. The genus Ureaplasma is biochemically unique in that all members possess urease and therefore hydrolyze urea to produce adenosine triphosphate. Ammonia, which increases the pH and limits growth in culture, is also produced. Ureaplasma urealyticum was first described…

Other Mycoplasma Species

Many Mollicutes colonize the mucosal surfaces of humans ( Table 197.1 ). Of these, only Mycoplasma genitalium , M. hominis , M. pneumoniae (see Chapter 196 ) , and Ureaplasma urealyticum (see Chapter 198 ) are known to be pathogenic for healthy humans. Other Mycoplasma species have been isolated in pure culture from nonmucosal sites in immunocompromised people, indicating that commensal species can cause disease in…