Sensing and Detection With Cardiac Implantable Electronic Devices

In cardiac implantable electronic devices (CIEDs), sensing is the process for identifying the electrical signals (electrograms, EGMs) that correspond to individual atrial or ventricular depolarization. Detection is the process by which device algorithms classify a sequence of sensed signals to determine the cardiac rhythm. Thus basic sensing precedes detection. Characteristics of Cardiac Electrograms Electrograms (EGMs) are the graphical display of temporal changes in electric potentials recorded…

Stimulation and Excitation of Cardiac Tissues

This chapter reviews the fundamental concepts of artificial electrical cardiac stimulation, including the cellular aspects of myocardial stimulation, the influence of external current on cardiac tissue, waveform, and electrode considerations, clinical applications and considerations, and ongoing research regarding cardiac stimulation. The cardiac myocardium is characterized by the capacity for spontaneous initiation of rhythmic beating, excitability with the opening and closing of membrane ion channels resulting in…

Imaging of Cardiac Anatomy

Over the last two decades advanced imaging technologies, including cardiac magnetic resonance (CMR), computed tomography (CT), and three-dimensional transesophageal echocardiography (3D TEE), have evolved to allow acquisition of exquisite anatomic details of cardiac structures, in both two- and three-dimensional (2D and 3D) format and have become an essential component of the diagnosis and management of patients with all forms of cardiovascular diseases. Cardiac imaging particularly plays…

Cardiac Anatomy and Pathology

It has been 500 years since the birth of Andreas Vesalius, the father of anatomy. In his most important and influential work, “De Humani Corporis Fabrica Libri Septem,” published in seven volumes between 1543 and 1555, Vesalius demonstrated the importance of dissection of cadavers for detailed knowledge of human anatomy. Historically, anatomy is a fundamental part of the medical curriculum. These days, to greater or lesser…

Ventricular arrhythmias

Definitions Ventricular tachycardia (VT) is defined as a tachycardia (rate > 100 beats per minute [bpm]) with three or more consecutive beats that originates in the ventricles. , Accelerated idioventricular rhythm denotes a ventricular rhythm less than 100 bpm. Sustained ventricular tachycardia lasts more than 30 seconds (unless requiring termination because of hemodynamic collapse), whereas nonsustained tachycardia terminates spontaneously within 30 seconds. Monomorphic ventricular tachycardia has…

Wolff-Parkinson-White syndrome and atrioventricular reentrant tachycardias

Definitions The anatomic basis of atrioventricular reentrant tachycardia (AVRT) is an abnormal connection ( accessory pathway [AP] ) between the atrial and ventricular myocardium. One limb of the reentrant circuit is the atrioventricular (AV) node and the other is the AP. On rare occasions the circuit includes two or more APs. The term preexcitation refers to earlier activation of the ventricle by a wave front arising…

Atrioventricular junctional tachycardias

Atrioventricular nodal reentrant tachycardia Definition Atrioventricular nodal reentrant tachycardia (AVNRT) denotes reentry in the area of the atrioventricular (AV) node. Several models have been proposed to explain the mechanism of the arrhythmia in the context of the complex anatomy of the AV node and its atrial extension, but its exact circuit remains elusive. Pathophysiology The concept of dual AV nodal pathways as the substrate for AVNRT…

Atrial fibrillation

Definitions and classification Atrial fibrillation (AF) is characterized by uncoordinated atrial activation without effective atrial contraction. On the electrocardiogram (ECG), AF is characterized by rapid oscillations or fibrillatory waves that vary in amplitude, shape, and timing; that usually have a cycle length less than 200 ms; and that are associated with an irregular ventricular response. QRS complexes may also be of variable amplitude. Regular R-R intervals…

Atrial tachycardias

Atrial premature beats An atrial premature beat (APB) is characterized by a nonsinus P wave that occurs before the next anticipated sinus beat. Several electrocardiographic leads may be needed to distinguish P waves originating in the sinus node versus an ectopic focus. In the rare case of sinus nodal premature beats, the P wave will be identical. The post-extrasystolic cycle length is typically less than compensatory…

Differential diagnosis of wide-QRS (>120 ms) tachycardias

Wide-QRS tachycardias can be ventricular tachycardia (VT), supraventricular tachycardia (SVT) conducting with bundle branch block (BBB) aberration or through a bystander accessory pathway (AP), or an AP-mediated tachycardia, with reported proportions of 80%, 15%, and 5%, respectively. , The correct diagnosis of VT is critical to management because misdiagnosis and administration of drugs usually used for SVT can be harmful for patients in VT. Therefore the…

Differential diagnosis of narrow-QRS (≤120 ms) tachycardias

Narrow-QRS complexes (≤120 ms) are due to activation of the ventricles via the His-Purkinje system, consistent with origin of the arrhythmia above or within the His bundle. However, early activation of the His bundle can also occur in high septal ventricular tachycardias (VTs), thus resulting in relatively narrow-QRS complexes (110–140 ms). In these cases the HV interval is less than 35 ms. Atrial fibrillation (AF) with…

Investigation of bradycardias

Sinus bradycardia Sinus rates less than 60 beats per minute (bpm) are defined as bradycardia in adults. , Lower rates are common in well-trained athletes and occasionally in the young. During sleep the sinus rate may fall to 35 bpm with pauses up to 3 seconds and this is not considered abnormal. Sinus arrhythmia usually refers to sinus cycle phasic variation that is related to the…

Physics of ablation

Radiofrequency ablation Radiofrequency (RF) ablation induces tissue necrosis by heating the targeted tissue. Most cardiac ablation systems deliver RF energy between a unipolar platinum-iridium electrode at the tip of the ablation catheter and a large dispersive grounding patch on the patient’s skin, typically on the abdomen or thigh ( Fig. 8.1 ). Ablation catheters also have electrodes to record electrical activity from within the heart (…

Electroanatomic mapping and magnetic guidance systems

Electroanatomic mapping Theoretical considerations During conventional electrophysiology (EP) procedures, catheters are manually navigated with the use of single or bi-plane fluoroscopy. An inherent limitation of fluoroscopic navigation is that orientation of the catheter relative to the cardiac anatomy can only be appreciated in two dimensions. Thus it may make complex procedures challenging and is associated with radiation exposure for both patient and physician. In 1996 Ben-Haim…

Basic intervals and atrial and ventricular conduction curves

Basic intervals Basic intervals during sinus rhythm represent a quantitative assessment of the electrical activation of the heart. Normal atrial activation begins at the sinus node, spreads to the low atrium and atrioventricular (AV) junction, and then to the left atrium ( Fig. 6.1 ). Occasionally, the low-right atrium is activated slightly later than the atrium recorded at the AV junction. Activation of the left atrium…

Electrophysiology hardware

Electrode catheters Basic mapping catheters Catheters used for electrophysiology studies (EPSs) and ablation are composed of multiple insulated wires encased in woven Dacron or polyurethane. Electrodes used in electrophysiology (EP) catheters are usually made of polished platinum-iridium alloy. Platinum is an inert and biologically safe metal with excellent electrical properties but is mechanically soft. The addition of iridium improves mechanical strength without affecting electrical performance. Electrode…

Vascular access and catheter placement

Patient preparation Patients should be studied in the postabsorptive state and after beta blockers or other antiarrhythmic agents have been discontinued for at least 5 days. Amiodarone should be withdrawn at least 2 months before the procedure if feasible. A transesophageal echocardiogram is recommended to exclude intracardiac thrombi in patients with atrial fibrillation (AF) or atrial flutter and is particularly important in such patients who have…

Cardiac anatomy for the electrophysiologist

Some of the descriptive terms conventionally used for cardiac structures are inaccurate. Conventionally the heart and its associated structures have been described in accordance with their position when the heart has been removed from the body and positioned with the apex down, rather than according to their in vivo positions. , For example, when defining positions along the mitral and tricuspid valve annuli and the triangle…

Electrophysiologic mechanisms of arrhythmogenesis

Normal excitation of the heart Cardiac electrical activity starts by the spontaneous excitation of “pacemaker” cells in the sinoatrial node in the right atrium. Pacemaker automaticity is due to spontaneous diastolic repolarization of phase 4 that generates rhythmic action potentials and determines the heart rate through various currents, including the If current. There are no histologically specialized conduction tissues between the sinus and AV node, and…

Classification of arrhythmias

Bradyarrhythmias are due to sinus nodal disease ( Box 1.1 ) or atrioventricular conduction block ( Box 1.2 ). Box 1.1 Sinus Node Dysfunction (with accompanying symptoms) Sinus bradycardia Sinoatrial exit block Sinus pauses (>3 s) Sinus node arrest Tachycardia-bradycardia syndrome Chronotropic incompetence * * Maximum predicted heart rate is calculated as 220 – age (y). Box 1.2 AV. Atrioventricular. Atrioventricular Block First-degree AV block Second-degree…