Nephrogenic rests and nephroblastomatosis


  • Nephrogenic rests are abnormally persistent embryonal cells beyond 36 weeks of gestation and are associated with and capable of developing into nephroblastomas (Wilms tumor).

  • Nephroblastomatosis is defined as the presence of diffuse and multifocal nephrogenic rests.

Clinical features


  • Encountered in 40% of patients with unilateral nephroblastoma and nearly 100% of patients with bilateral nephroblastomas

  • Observed in 1% of infant autopsies

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