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Wilms tumor


Definition

  • A renal tumor derived from nephrogenic blastemal cells that recapitulate the histology of the developing kidney at various stages with divergent patterns of differentiation; also known as nephroblastoma

Clinical features

Epidemiology

  • Affects 1/8000 to 1/10,000 children, with no sex predilection

  • The most common renal tumor in children

  • The most common genitourinary cancer in children

  • Accounts for 8% of all pediatric cancers

  • Ninety-eight percent of patients younger than 10 years

  • Patient mean age: 37 months for males and 43 months for females

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