Mucosal melanoma of the genitourinary system


  • Primary melanoma originating from the mucosa of the genitourinary system

Clinical features


  • Rare, but more common in women (female/male=10:1)

  • Incidence increases with age

  • Most commonly involving urethra, penis, scrotum; rarely reported in prostate, bladder, and ureter

  • Mean age, 64 years (range, 50–77 years)

  • Rare in patients of African ancestry

  • Urethral melanoma more common in female patients; no racial difference

  • Risk factors: pre-existing nevi, exposure to ultraviolet radiation, history of melanoma

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