Lymphadenopathy is a common presenting condition. It may be localised or generalised. The causes are multiple but a careful history and clinical examination will often simplify the diagnosis. Lymphadenopathy, especially cervical, is extremely common in children who are otherwise healthy. Painful tender nodes are usually associated with infection. Firm or hard, painless nodes are commonly the seat of malignancy. Only the more common causes, which the student would be expected to know, are described in this section.

Causes

Primary infection

Viral

  • Infectious mononucleosis

  • HIV

  • CMV

  • Rubella

  • Measles

Bacterial

  • TB • (common in parts of the world where TB is endemic)

  • Syphilis

  • Brucellosis

  • Cat scratch disease

  • Septicaemia

Protozoal

  • Toxoplasmosis

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