Hypercalcaemia is a serum calcium >2.62 mmol/L (normal range 2.1–2.6 mmol/L). It may be an asymptomatic laboratory finding. Symptoms usually become apparent with levels >3.50 mmol/L.

Causes

  • Malignancy

    • Solid tumour with lytic bony metastases, e.g. Ca breast, bronchus

    • Solid tumours with humoral mediation, e.g. inappropriate PTH secretion with carcinoma of the bronchus, carcinoma of the kidney

    • Multiple myeloma

  • Hyperparathyroidism (primary, secondary, tertiary)

  • Hyperthyroidism

  • Drugs, e.g. thiazide diuretics, lithium

  • Addison’s disease

  • Paget’s disease of bone

  • Excess intake of vitamin A, vitamin D or calcium

  • Sarcoidosis

  • Familial hypocalciuric hypercalcaemia

You're Reading a Preview

Become a Clinical Tree membership for Full access and enjoy Unlimited articles

Become membership

If you are a member. Log in here