Gonorrhea

The prevalence of gonorrhea is decreasing, with 106.1:100,000 as of 2013.

Most common in people ages 15–24 y, in large urban areas, and among people with low socioeconomic status and/or low levels of education.

Incidence higher in men; prevalence higher in women.

Sexually transmitted disease.

High incidence of coexisting chlamydial infection.

Local infection: Purulent, profuse urethral discharge and possible epididymitis, prostatitis, or proctitis in men. It is often asymptomatic in women, but may have cervical discharge, vaginitis, salpingitis, or proctitis. Ascending infection may lead to PID.

Disseminated infection: Fever/rash, tenosynovitis/arthritis (common), conjunctivitis (usually from autoinoculation), possible myopericarditis, and toxic hepatitis or perihepatitis (Fitz-Hugh-Curtis syndrome), rarely with endocarditis or meningitis.

Neisseria gonorrhoeae: G ram-negative intracellular diplococcus, usually found inside polymorphonucleocytes.

Humans only natural hosts for N. gonorrhoeae.