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Felodipine
See also Calcium channel blockers
General information
Felodipine is a dihydropyridine derivative with diuretic properties [ ]. Its diuretic properties are not unique but are shared by other dihydropyridines. Vasodilatory adverse reactions include flushing, headache, and tachycardia [ , ]. Reduced arterial oxygen saturation has been seen in patients given intravenous felodipine for pulmonary hypertension [ , ]. Along with amlodipine, but unlike other calcium channel blockers, felodipine may be safer in severe chronic heart failure accompanied by angina or hypertension.
Organs and systems
Mouth
Felodipine-associated gingival enlargement has been reported in a patient with type 2 diabetes [ ]. The changes resolved after withdrawal of felodipine and control of the diabetes, and there were further improvements after scaling and root planing and instruction about oral hygiene. The histological features, elongated rete pegs, fibrous hyperplasia, a low-grade chronic inflammatory infiltrate, predominantly consisting of lymphocytes, and collagen bundle groups randomly distributed, were similar to those present in other cases of drug-associated gingival enlargement.
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