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Ebastine
See also Antihistamines
General information
Ebastine is a second-generation antihistamine with proven efficacy in the treatment of allergic disease [ ]. It is rapidly absorbed after oral administration, and undergoes extensive first-pass metabolism by CYP3A4 to its active carboxylic acid metabolite, carebastine.
Organs and systems
Cardiovascular
Cardiac effects were reported from early experimental work using very high doses of ebastine, but they are not believed to be clinically relevant in normal use. In one study serial electrocardiograms showed no changes with doses up to the maximum used (30 mg). Ebastine in doses up to five times the recommended therapeutic dose did not cause clinically relevant changes in QT c interval in healthy subjects [ ]. Co-administration of ebastine with ketoconazole or erythromycin did not lead to significant changes in the QT c interval [ , ].
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