Comprehensive Diagnostic Transthoracic and Transesophageal Echocardiography


Echocardiography is the most commonly used imaging modality for the evaluation of cardiac anatomy and function; it allows comprehensive evaluation of left ventricular (LV) and right ventricular (RV) function, regional wall motion, valvular heart disease, and pericardial disease, as well as estimation of pulmonary pressures and central venous pressure. Comprehensive transthoracic echocardiography (TTE) consists of a combination of two-dimensional (2D), M-mode, and Doppler imaging, with three-dimensional echocardiography (3DE; see Chapter 1 ) increasingly being incorporated into imaging protocols. Appropriate use criteria for multimodality imaging address the use of TTE in the diagnosis and management of valvular and structural heart disease ( Table 8.1 ). , Echocardiography is appropriate for the diagnosis and clinical management of cardiac diagnoses but is rarely indicated when results would not likely alter the course of treatment.

TABLE 8.1
Common Appropriate Indications for TTE as a Diagnostic Test.
Adapted from Doherty JU, Kort S, Mehran R, Schoenhagen P, Soman P. ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 appropriate use criteria for multimodality imaging in valvular heart disease: a report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Coll Cardiol . 2017;70:1647–1672; and Doherty JU, Kort S, Mehran R, et al. ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2019 appropriate use criteria for multimodality imaging in the assessment of cardiac structure and function in nonvalvular heart disease: a report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and the Society of Thoracic Surgeons. J Am Coll Cardiol . 2019;73:488–516.
Appropriate
Valvular heart disease (VHD) or structural heart disease
Pulmonary arterial hypertension
Presyncope or syncope
Hypotension or hemodynamic instability
Hypertensive heart disease
Respiratory failure or shortness of breath of uncertain etiology
Infective endocarditis (IE)
Cardiac mass, tumor, or thrombus; potential cardiac source of emboli
Arrhythmia or conduction disorder
Complications of myocardial ischemia or infarction
Candidacy for and optimization of implantable cardioverter-defibrillator/cardiac resynchronization therapy and ventricular assist device
Pericardial disease
Acute aortic pathology including acute aortic syndrome
Re-evaluation (3–5 years) of stage A (bicuspid aortic valve or aortic sclerosis) VHD or stage B (mild) VHD
Re-evaluation (1–2 years) of stage B (moderate) VHD
Re-evaluation (6–12 months) of stage C1 (asymptomatic and severe) VHD
Follow-up testing of new or worsening symptoms in VHD, IE, or structural heart disease
Preoperative, perioperative, and postoperative evaluation of surgical valve replacement or repair
Preprocedural, periprocedural, and postprocedural evaluation of structural heart disease intervention procedures
Rarely Appropriate
Transient fever and pathogen not typically associated with IE, a documented nonendovascular source of infection, no bacteremia, and/or no evidence of a new murmur
Preparticipation athletics assessment in a patient with no symptoms, normal examination findings, and no family history of congenital heart disease

Transesophageal echocardiography (TEE) is a semi-invasive procedure that is widely used for a range of clinical applications, including diagnostic, intraprocedural, and real-time cardiac monitoring. Compared with TTE, TEE allows improved visualization of most cardiac structures and is indicated when TTE imaging is likely to be nondiagnostic or when highly detailed images are needed (e.g., imaging of prosthetic valves). Advances in image processing and display, the addition of 3DE, and the relative portability of ultrasound systems have dramatically increased the availability and utility of TEE in a variety of clinical settings, including the cardiac catheterization laboratory, operating room, and intensive care unit.

The Diagnostic Transthoracic Echocardiogram

Nomenclature

Echocardiographic acoustic windows are transducer positions that allow ultrasound access to the heart, and views are cardiac imaging planes that are transected by the transducer beam. Transthoracic images are typically obtained from four primary acoustic windows: left parasternal, apical, subcostal, and suprasternal notch ( Fig. 8.1 ).

Fig. 8.1, Echocardiographic windows and standard imaging planes of the heart.

Standard imaging planes are used as reference for each echocardiographic view:

  • 1.

    The long-axis plane lies parallel to the long axis of the LV, transects the LV apex and the center of the aortic valve (AV), and is aligned with the anteroposterior diameter of the mitral valve (MV).

  • 2.

    The short-axis plane is perpendicular to the LV long axis and allows visualization of cross-sections of the LV, MV, and AV, depending on the level along the long axis that is transected.

  • 3.

    The 4-chamber plane is oriented orthogonal to the long- and short-axis views of the LV; this plane transects both atria and ventricles and is aligned with the mediolateral diameter of the MV and tricuspid (TV) valves.

  • 4.

    The 2-chamber plane is oriented from apex to base and lies orthogonal to the short-axis view of the LV.

Patient and Transducer Position

TTE is performed by a physician or cardiac sonographer. Time needed to perform a TTE examination ranges from minutes for rapid assessment of a critically ill patient to a lengthier study for a comprehensive evaluation, such as in patients with complex valvular heart disease (VHD) or congenital heart disease. The sonographer is typically sitting at the patient’s left side, with the patient lying in a supine or left lateral decubitus position; this improves ultrasound windows by bringing the heart anteriorly and lateral to the sternum. Adjustments of the transducer on the chest wall, obtained by tilting, sweeping, rotating, sliding, rocking, and angling the transducer, produce different imaging views as the ultrasound beam is directed through the heart at different angles ( Fig. 8.2 ). Guidelines for the performance of a comprehensive TTE examination were published by the American Society of Echocardiography in 2019.

Fig. 8.2, Transducer movements.

Parasternal Window

Parasternal Long-Axis View

For the left parasternal window, the patient is placed in a left lateral decubitus position with the transducer in the third or fourth left intercostal space. The LV long-axis view is obtained with the transducer index marker facing toward the patient’s right shoulder at approximately the 10-o’clock position (see Fig. 8.2C ). This view allows visualization of the LV, left atrium (LA), MV, AV, and proximal ascending aorta ( Fig. 8.3 ). The LV should lie perpendicular to the ultrasound beam, with the anterior (AMVL) and posterior (PMVL) mitral valve leaflets and the right and noncoronary cusps of the AV visualized ( Table 8.2 ). With increased depth in the imaging sector, the parasternal long-axis view (PLAX) allows differentiation of pericardial and pleural effusions: the oblique pericardial sinus lies between the LA and the descending thoracic aorta, and a pericardial effusion lies between these two structures, whereas a pleural effusion tracks posterior to the descending thoracic aorta (see Fig. 8.3B ). The size of a pericardial effusion does not necessarily correlate with hemodynamic impact. In this view, the true LV apex is not visualized; rather, the “apex” is typically an oblique image plane through the anterolateral wall.

Fig. 8.3, Parasternal long-axis view.

TABLE 8.2
Components and Proposed Sequence of a Comprehensive TTE Study.
Sequence Window View Modality Structures Evaluated and Measurements
1. Parasternal PLAX (maximum depth) 2D Overview of the heart and pericardial and pleural spaces
2D Descending aorta, coronary sinus
2. PLAX (standard depth) 2D LV, aorta, AV, MV
3. 2D Cardiac dimensions: LA: anterior-posterior diameter at end-systole
4. 2D Cardiac dimensions: LV, interventricular septum
5. 2D guided M-mode (M-mode cursor at MV leaflet tips) Cardiac dimensions: maximum LV dimension (end-diastole), minimum LV dimension (end-systole)
6. 2D Ascending aorta maximum diameter (end-diastole)
7. Color Doppler MV, AV
8. RV inflow 2D RA, TV, RV
9. Color, CW Doppler TR jet
10. PSAX 2D LV (papillary muscle sweep to apex)
11. 2D, color Doppler MV, AV
12. 2D, color, CW Doppler RVIT/TV/TR jet (peak velocity)
13. 2D, color, PW, CW Doppler RVOT, PV/PA bifurcation
14. Apical 4- and 5-chamber (maximum depth) 2D Descending aorta
15. 4- and 5-chamber (standard depth) 2D LV, RV
16. 2D Coronary sinus, LA (area, height in 4-chamber view), RA
17. 2D AV (5-chamber view)
18. 4-chamber (decrease depth or zoom) 2D LV endocardial border tracing (end-systole, end-diastole), biplane EF
19. 4-chamber (decrease depth or zoom) 2D LA height and volume tracing (end-systole), biplane volume
20. 2-chamber (standard depth) 2D
21. 2-chamber (decrease depth or zoom) 2D LV endocardial border tracing (end-systole, end-diastole), biplane EF
22. 2-chamber (decrease depth or zoom) 2D LA volume tracing (end-systole), biplane volume
23. LAX (standard depth) 2D
24. RV (standard depth) 2D
25. Color, CW Doppler TV (TR, peak velocity)
26. RV focused (standard depth) 2D RV diameter (distal to the TV annulus)
27. M-mode RV systolic function (TAPSE)
28. Tissue Doppler RV systolic function (systolic excursion at the basal RV free wall)
29. 4- and 5-chamber 2D, color Doppler MV, TV, LVOT, AV, interatrial septum
30. 4-chamber PW Doppler Diastology: MV E- and A-wave velocities (leaflet tips, MV deceleration time, and MV annulus a wave duration
31. 4-chamber Tissue Doppler Septum, lateral wall (maximum e ′ velocity 1 cm distal to the MV annulus)
32. PW Doppler Pulmonary vein: peak velocity, A-wave duration, systolic and diastolic waves
33. PW Doppler IVRT
34. PW Doppler LVOT peak velocity
35. CW Doppler, Pedof probe Valvular anatomy and function: MV (MR), AV (AI), TV (TR, peak velocity)
36. Subcostal 2D, M-mode LV, RV, LA, RA, IVC diameter
37. PW TR severity: IVC/HV confluence
38. 2D, color, PW Doppler Abdominal aorta
39. Suprasternal notch LAX 2D Aorta and take-off of the great vessels
40. Color, PW or CW Doppler Descending thoracic aorta
AI , Aortic insufficiency; AV , aortic valve; CW , continuous wave; EF , ejection fraction; HV , hepatic vein; IVC , inferior vena cava; IVRT , isovolumic relaxation time; LAX , long-axis view; LVOT , left ventricular outflow tract; MR , mitral regurgitation; MV , mitral valve; PA , pulmonary artery; PLAX , parasternal long-axis view; PSAX , parasternal short-axis view; PV , pulmonic valve; PW , pulsed wave; RVIT , right ventricular inflow tract; RVOT , right ventricular outflow tract; TAPSE , tricuspid annular plane systolic excursion; TR , tricuspid regurgitation; TV , tricuspid valve.

RV Inflow View

The RV inflow view is obtained by tilting the transducer inferomedially from the PLAX and rotating it slightly clockwise. In this view, the right atrium (RA), TV, and RV are visualized in a long-axis plane. The TV anterior leaflet is present along with the posterior leaflet. The coronary sinus enters the RA adjacent to the posterior tricuspid annulus, and the inferior vena cava (IVC) enters the RA inferior to the coronary sinus ( Fig. 8.4 ).

Fig. 8.4, RV inflow view.

Parasternal Short-Axis Views

The parasternal short-axis (PSAX) views are obtained by rotating the transducer 90 degrees clockwise from the PLAX, with the transducer index marker pointed toward the left supraclavicular fossa at approximately the 2-o’clock position, placing the ultrasound beam perpendicular to the LV long-axis plane. By tilting the transducer superiorly or inferiorly, different cross-sectional views of the heart may be visualized.

When the transducer is tilted superiorly, a transverse view of the heart is recorded at the level of the great vessels. In this view, the AV, LA, interatrial septum (IAS), RA, TV, and RV outflow tract (RVOT) are visualized. The right, left, and noncoronary cusps of the AV are seen, with the IAS attached just adjacent to the noncoronary cusp. The right coronary cusp is positioned anteriorly and abuts the RVOT; the left coronary cusp is adjacent to the proximal pulmonary artery (see Table 8.2 ). The origins of the left main and right coronary arteries can often be identified in this view.

For the MV short-axis view, the transducer is tilted inferiorly so that the ultrasound beam transects the heart at the level of the mitral leaflets. In this view, the AMVL and PMVL are seen en face. Each leaflet is segmented into three major scallops, called lateral (A1 and P1), middle (A2 and P2), and medial (A3 and P3), respectively ( Fig. 8.5A ). If the transducer is tilted further inferiorly, a cross-sectional view is obtained at the mid-ventricular (papillary muscle) level. In this view, a normal LV appears circular in shape, and the anterolateral and posteromedial papillary muscles are present at approximately the 3- and 8-o’clock positions, respectively (see Fig. 8.5B ).

Fig. 8.5, Parasternal short-axis views.

Apical Window

Apical 4-Chamber View

The apical window is obtained by placing the transducer at the point of maximal impulse, with the patient in the left lateral decubitus position. Rotation of the transducer allows for acquisition of the apical views. For the apical 4-chamber view, the ultrasound beam is directed medially and superiorly toward the patient’s right scapula, with the transducer index marker at approximately 3 o’clock. In this view, all four chambers of the heart, the IAS, and the interventricular septum (IVS) are visualized ( Fig. 8.6 ; see Table 8.2 ). The LV appears as a truncated ellipse with visualization of the anterolateral wall, apex, and inferoseptum. The AMVL is adjacent to the septum, and the PMVL is adjacent to the lateral wall.

Fig. 8.6, Apical views.

The tricuspid annulus is more apically positioned than the mitral annulus, with insertion of the septal TV leaflet up to 1 cm displaced relative to the AMVL insertion. This anatomic distinction aids in the identification of cardiac chambers if there is ambiguity in the orientation of the heart. The atria and the IAS are also visualized in this view; however, ultrasound resolution is often limited due to their distal positions relative to the transducer. Rotation of the transducer from the apical window allows visualization of all 17 myocardial segments ( Fig. 8.7 ). Slight counterclockwise rotation of the transducer produces the RV-focused view ( Fig. 8.8 ). RV size and function parameters obtained from the RV-focused view are more reproducible than those measured from the apical 4-chamber view.

Fig. 8.7, Standard echocardiographic imaging planes and the standard 17-segment model.

Fig. 8.8, RV size and function measurements.

Apical 2-Chamber and Long-Axis Views

Rotating the transducer counterclockwise approximately 60 degrees from the apical 4-chamber view provides the apical 2-chamber view. The anterior LV wall and the P1 scallop of the MV are seen on the right of the display, whereas the inferior wall and P3 scallop are seen on the left (see Fig. 8.7 ). Ejection fraction is calculated with the use of geometric assumptions based on the areas traced from end-diastolic and end-systolic frames in the apical 4-chamber and 2-chamber views ( Fig. 8.9 ).

Fig. 8.9, Apical biplane LV volumes.

Longitudinal strain is another measurement used for the evaluation of LV function ( Fig. 8.10 ; see Chapter 2 ). By convention, strain percentages are reported as negative for shortening. Averaged values from multiple regions provide global measures of LV function such as global longitudinal strain (GLS) (see Fig. 8.10B ).

Fig. 8.10, Speckle tracking strain imaging.

An additional 60 degrees counterclockwise rotation of the transducer yields the apical long-axis view, which is analogous to the image plane for the PLAX but with the transducer now positioned at the point of maximal impulse (see Figs. 8.6 and 8.7 ). Although the LV apex is now visualized in the apical long-axis view, image resolution for the AV, MV, and LV outflow tract (LVOT) is now relatively poorer because of the greater imaging depth from the transducer.

Subcostal Window

Subcostal imaging is performed with the patient in a supine position and knees flexed to relax the abdominal muscles and minimize patient discomfort during optimal transducer placement in the subxiphoid region. The transducer index marker should be pointed toward the patient’s left shoulder. Analogous to the apical 4-chamber view, all four chambers of the heart are visualized, including the RV free wall, inferoseptal LV wall, and anterolateral LV wall ( Fig. 8.11 ; see Table 8.2 ). However, because of increased distance between the cardiac apex and the transducer, the LV apex is commonly foreshortened or poorly visualized. One benefit of this view is the perpendicular orientation of the imaging plane relative to the interatrial and interventricular septa, which allows for visualization of atrial and ventricular septal defects. This view is particularly useful for the detection of sinus venosus atrial septal defects because it enables visualization of the superior portion of the IAS. Counterclockwise 90-degree rotation of the transducer yields the subcostal LV short-axis view.

Fig. 8.11, Subcostal 4-chamber view and suprasternal notch view.

From the subcostal 4-chamber view, rotating the transducer counterclockwise with angulation to the patient’s left side yields a long-axis view of the IVC as it enters the RA. The dimensions of the IVC and its change in size in response to negative intrathoracic pressure produced by respiration and intentional sniff allow estimation of right atrial pressure (RAP). The IVC should be evaluated 1 to 2 cm proximal to the junction of the RA. In normal individuals (RAP = 3 mmHg), the diameter perpendicular to the IVC long axis should be less than 2.1 cm and should have greater than 50% collapse with an inspiratory sniff. An elevated RAP of 15 mmHg is estimated when the IVC diameter is greater than 2.1 cm and there is insufficient inspiratory collapse. The proximal abdominal aorta may be imaged from the subcostal view by angulating the probe toward the patient’s right side; this is an important evaluation for incidental abdominal aortic aneurysm.

Suprasternal Notch Window

To facilitate imaging from the suprasternal notch window, the patient’s neck should be comfortably hyperextended to create space for transducer placement. This may be achieved by placing a pillow behind the patient’s shoulders with the patient lying supine. The suprasternal long-axis view is recorded with the transducer index marker directed toward the left supraclavicular region (approximately the 2-o’clock position). In this view, the aortic arch, the origin of the brachiocephalic arteries, and the descending thoracic aorta are visualized. A cross-sectional view of the right pulmonary artery (RPA) is just under the aortic arch (see Fig. 8.11B ). Rotating the transducer clockwise, perpendicular to the long-axis view, shows the aortic arch in cross-section and the RPA in long axis. Although they are not easily visualized due to their distance from the transducer, the suprasternal short-axis view is the only view in which all four pulmonary veins entering the LA may be concurrently imaged.

M-Mode Echocardiography

M-mode echocardiography plays an important role in comprehensive cardiac assessment. M-mode tracings are displayed as a single scan line from the transducer located in a selected position within the sector width. Depth is displayed on the vertical axis against time on the horizontal axis. The rapid sampling rate of M-mode echocardiography yields excellent temporal resolution, providing precise measurements of cardiac dimensions, and allows the sonographer to more accurately evaluate highly mobile structures and assess the timing of motion in these structures. M-mode recordings should be obtained with guidance from 2D echocardiographic imaging for optimal placement of the M-mode cursor.

In the PLAX view, M-mode tracings are obtained for the evaluation of LV chamber size (measured at the level of MV tip coaptation), MV, AV, and LA. Although measurements of the LV from M-mode are limited because of their one-dimensional spatial representation, they are typically accurate and reproducible in evaluating disease processes that result in symmetric changes to the LV, such as volume overload and hypertrophy.

A 2D-guided M-mode recording at the MV level is useful in the evaluation of LV systolic function, aortic insufficiency, and hypertrophic obstructive cardiomyopathy. For example, an increased E-point septal separation, which is the distance between the septal wall and the E-point (point of maximum excursion of the AMVL toward the IVS in early diastole) indicates LV dilation and systolic dysfunction. Abnormal motion of the AMVL may suggest an underlying pathology (e.g., fluttering of the leaflet in the setting of aortic insufficiency). M-mode recordings through the proximal ascending aorta at the level of the AV leaflet tip are useful for evaluating AV pathologies. For example, thickened cusps and reduced AV opening during systole suggests valve stenosis, and thin cusps with early closure indicate prevalve systolic obstruction, which can occur in hypertrophic cardiomyopathy ( Fig. 8.12A ).

Fig. 8.12, M-mode imaging.

M-mode examination is also used in the evaluation of pulmonary hypertension, RV dysfunction, and pericardial effusion and tamponade. A classic finding in pulmonary hypertension is mid-systolic closure (i.e., notching) of pulmonic valve motion, which produces a characteristic flying W shape (see Fig. 8.12B ). RV systolic function is gauged by the evaluation of tricuspid annular plane systolic excursion (TAPSE) on apical M-mode recording. In patients with hemodynamically significant pericardial effusions, directing the M-mode scan line through the RV free wall can demonstrate early diastolic collapse and respiratory variability in cardiac chamber size.

Doppler Echocardiography

Doppler echocardiography and color-flow Doppler are essential parts of the complete echocardiographic examination. Doppler echocardiography complements 2D and M-mode assessments of cardiac structure, providing important hemodynamic information.

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