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Chronic obstructive pyelonephritis
Definition
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Pathologic changes secondary to chronic obstruction of the urinary outflow
Clinical features
Epidemiology
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Obstruction is more common in males during childhood (ureteropelvic obstruction, posterior urethral valves, and other congenital anomalies), in females during adulthood (gynecologic diseases), and in males at an older age (prostatic diseases).
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Increased pressure, reflux of urine with leakage into the interstitium, and ischemia of the inner medulla are key factors promoting atrophy and fibrosis of the renal parenchyma.
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