Introduction It seems as if surgeons have always debated the “proper” treatment of colorectal injuries, including the following issues: When should continuity be restored, and when should diversion be implemented? Should left-sided colon injuries be treated differently from right-sided colon…
Introduction Intestinal ischemia produces a spectrum of diseases affecting the gastrointestinal tract. These syndromes, which can be acute or chronic, can affect the upper abdominal viscera, as well as the small intestine, colon, and rectum. They account for significant morbidity…
Introduction Nonepithelial tumors of the colon and rectum are rare and represent fewer than 1% of all neoplasms of the colon and the rectum. They can be categorized as benign or malignant. In this chapter we will briefly discuss benign…
Introduction Colorectal carcinoma metastasizes to the lung in 10% to 15% of patients. The decision about whether to perform surgery for a patient with lung metastasis must take into account the patient’s ability to tolerate surgery, as well as the…
Introduction The liver is the most common site for colorectal cancer (CRC) metastases; 15% to 20% of patients present with synchronous lesions, and metachronous metastases occur in 40% to 50% of patients. Liver metastases are present in 60% to 70%…
Acknowledgments Dr. Khorana acknowledges research support from the Sondra and Stephen Hardis Endowed Chair in Oncology Research, the Scott Hamilton CARES Initiative, the Porter Family Fund for Biliary Genomics Research, and the National Heart, Lung and Blood Institute (1R34HL127156). Dr.…
Introduction Surgical resection is the primary curative treatment for patients with localized colorectal cancer. The most accurate prognostic indicator of colon cancer is its stage at diagnosis, and in patients with locally advanced disease, chemotherapy has a role in decreasing…
Introduction Malignant tumors of the appendix are rare, making up approximately 0.4% of all intestinal neoplasms. About 1% of all large bowel cancers arise from the appendix. The histopathology of appendiceal malignancy has been confusing, and the approach to therapy…
Introduction Approximately 5% of all colorectal cancers (CRCs) are associated with a hereditary syndrome, where a germline mutation in a key tumor suppressor or DNA repair gene produces a cancer predisposition that can be inherited. Hereditary nonpolyposis colorectal cancer (HNPCC)…
Introduction Desmoid disease is a benign proliferation of fibroblasts that produces a spectrum of manifestations from rapidly growing tumors to indolent nodules and flat sheets of tissue that distort surrounding organs. Although desmoid disease occurs in the general population, it…