D efinition — Poorly differentiated carcinomas in which a line of differentiation cannot be determined. Clinical Features Epidemiology Pure undifferentiated carcinomas are rare. Patients may present at a wide range of ages, with a mean age of 63 years. You’re…
D efinition — A variant of endometrioid carcinoma with neuroendocrine features. Clinical Features Epidemiology A variant pattern seen in poorly differentiated carcinomas of the endometrium. The vast majority of patients are postmenopausal with a median age in the sixth to…
D efinition — A common conundrum in endometrial cancer classification in which an endometrioid histology coexists with strong p53 staining. Clinical Features Epidemiology Outcomes for serous carcinoma are distinctly less favorable relative to both low- and high-grade endometrioid carcinomas. Some…
D efinition — A variant of endometrial carcinoma with two distinct differentiation patterns, usually separated, with minimal evidence of a histologic transition. Clinical Features Epidemiology Relatively uncommon. Can occur at any age. Presumed to be a single original clone followed…
D efinition — High-grade adenocarcinoma arising from the endometrium and invariably associated with mutations in the p53 tumor suppressor gene. Clinical Features Epidemiology Uterine serous carcinoma is relatively uncommon, comprising around 10% of endometrial primaries. Patients are most commonly in…
D efinition — A form of atypia associated with abnormal bleeding. Clinical Features Epidemiology Most commonly occurs in women in their fifth to seventh decades. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
D efinition — A form of hobnail atypia associated with adjacent necrosis or hyaline degeneration signifying regional ischemia. Clinical Features Epidemiology Most commonly occurs in women in their fifth to seventh decades who have endometrial polyps. You’re Reading a Preview…
D efinition — An early, noninvasive form of serous adenocarcinoma of the endometrium. Clinical Features Epidemiology Serous endometrial intraepithelial carcinoma (EIC) is a rare neoplasm. The vast majority of patients are postmenopausal. EIC is most commonly seen in a background…
D efinition — Epithelial proliferations with evidence of p53 mutations that do not fulfill the criteria for intramucosal carcinoma. Clinical Features Epidemiology These lesions are rare and occur around menopause. Occasionally seen in endometrial polyps. Link between p53 positive epithelium…
D efinition — Nonepithelial cells present during both benign and neoplastic conditions. Clinical Features Epidemiology/Significance Histiocytes are common in postmenopausal endometrial samples, often associated with surface injury or erosion. They do not confer an increased risk of malignancy. Foamy stromal…