Introduction In 1955, Robinson and Orr published the first report of isolated familial papillary thyroid cancer affecting 24-year-old identical twins. Twenty years later, Nĕmec and colleagues described differentiated thyroid cancer without environmental exposures in a mother and son. Since that…
Video 29.1 Introduction to Chapter 29, Pediatric Thyroid Cancer. Introduction Much like many childhood diseases, there are major differences in the diagnosis and management of pediatric patients with thyroid cancers compared with adults. This chapter highlights some of those differences…
Introduction Thyroid cancer incidence is rising rapidly, mostly due to increasing rates of incidentally detected papillary microcarcinoma. Anaplastic thyroid cancer (ATC), however, is a rare form of undifferentiated thyroid carcinoma. Even though the incidence for differentiated thyroid cancer (DTC) is…
Introduction As early as the beginning of the 20th century, medullary thyroid carcinoma (MTC) was noted as a distinct disease entity within the broad spectrum of malignant thyroid tumors. By the first half of the century, the peculiar tumor biology…
Video 26.1 Introduction to Chapter 26, Sporadic Medullary Thyroid Carcinoma. Introduction Medullary thyroid carcinoma (MTC) comprises 1% to 2% of all new cases of thyroid cancer in the United States, a number that is significantly smaller than historically documented, due…
Video 25.1 Introduction to Chapter 25, Hürthle Cell Tumors of the Thyroid. Introduction Hürthle cell carcinoma (HCC) of the thyroid gland is an uncommon tumor, accounting for 3% to 10% of all thyroid cancers, and therefore few institutions have significant…
Introduction A defined set of clinical factors and pathologic characteristics have been used in different staging systems (e.g., Tumor, Node, and Metastases [TNM] with American Joint Committee on Cancer [AJCC]; metastasis, age, completeness of resection, invasion, and size [MACIS]; age,…
Video 23.1 Introduction to [CR] , Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features. Introduction Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently defined entity that was accepted by the World Health Organization (WHO) in 2017.…
Introduction Follicular thyroid cancer (FTC) is a subset of follicular cell–derived thyroid cancer. It falls within the broad category of differentiated thyroid cancer (DTC) and is the second most common histologic subtype behind papillary thyroid cancer (PTC). Unlike PTC, the…
Video 21.1 Introduction to [CR] , Papillary Carcinoma Observation. Introduction Recognizing that the incidence of papillary microcarcinoma (PMC) detected on autopsy and clinical screening studies far exceeded the prevalence of clinically apparent thyroid cancer more than 20 years ago, Miyauchi…