Clinical case A 29-year-old G2P2 woman with a known bicornuate uterus presents to the office with irregular vaginal bleeding. A pelvic exam demonstrates a 2 cm friable lesion on the proximal vagina adjacent to the cervix ( Fig. 16.1 ).…
Introduction The overwhelming majority of cervical cancer cases will be either squamous cell or adenocarcinoma. In a National Cancer Database (NCDB) study of cervical cancer in the United States, 79.5% of cervical cancer cases consisted of the squamous cell subtype,…
Clinical case A 32-year-old G0 female presents with a newly diagnosed small cell neuroendocrine carcinoma (NEC) of the cervix. On physical exam, she is noted to have a 1.5 cm lesion on the anterior lip of the cervix with no…
Neuroendocrine tumors Epidemiology Incidence and mortality Neuroendocrine carcinomas (NEC) of the endometrium, which includes both small-cell and large-cell variants, are rare, highly aggressive tumors that account for approximately 0.8% of endometrial carcinomas. They generally present with advanced stage disease. The…
Clinical case A 64-year-old female presents to the Gynecologic Oncology clinic for a second opinion regarding a new diagnosis of uterine serous carcinoma. She originally presented to her gynecologist within the last 3 months complaining of postmenopausal vaginal spotting. Pelvic…
Clinical case A 75-year-old African American woman presents to your clinic with complaints of new onset vaginal bleeding. She has a past medical history significant for obesity and history of breast cancer managed with tamoxifen maintenance. On pelvic exam, she…
Clinical case A 51-year-old patient presents with abnormal uterine bleeding and a 6 cm intrauterine, polypoid mass on pelvic ultrasound imaging ( Fig. 10.1 ). Office endometrial biopsy (EMB) was suggestive of uterine adenosarcoma. She was taken to the operating…
Clinical case A 59-year-old nulliparous woman with history of multiple uterine fibroids status post myomectomy for abnormal uterine bleeding 20 years prior and recent total abdominal hysterectomy and salpingo-oophorectomy for recurrent, intermittent postmenopausal bleeding presented for management of pathological diagnosis…
Introduction Ovarian cancer encompasses a wide variety of tumors, all with different clinical patterns, histologies, and molecular features. Ovarian cancer is typically classified as epithelial (serous, mucinous, endometrioid, clear cell, carcinosarcoma, and mixed) vs nonepithelial (germ cell and sex cord…
Clinical case A 22-year-old G0 female presents with a newly diagnosed small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). She reported pelvic pain and her physical exam was within normal limits. Pelvic sonography identified a 5 cm complex cystic…