Acknowledgments This work is founded by The Italian Neuroblastoma Foundation “Fondazione Italiana per la Lotta al Neuroblastoma”. The authors would like to thank Carlo Zanon for his critical revision of the chapter. Introduction From the previous chapters, we have learned…
Acknowledgments This work is dedicated to the memory of Dr. Vito Pistoia, a leading expert in this field. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…
Introduction Cancer immunotherapy has been hailed as a potential “game changer” in the treatment of cancer. However, the number of antigen targets proven effective remains limited and is restricted to protein antigens, with the exception of Dinutuximab, a chimeric antibody…
Introduction Major strides have been made in targeted cancer therapy over the past decades due to better understanding of underlying cancer biology, identification of cancer vulnerabilities, and integration of multiple therapy approaches . These advances have led to the development…
Introduction Neuroblastoma is a sympathetic nervous system malignant tumor, which is derived from the neural crest cells and constitutes 7%–11% of the total number of childhood malignant tumors, taking fourth place in the structure of cancer morbidity after acute leukemia,…
Introduction Neuroblastoma is often used as a collective term for all types of peripheral neuroblastic tumors of neural crest origin and includes Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma. Historically tumors in this group were described as “enigmatic” because of their unique and…
Clinical Vignette A 55-year-old female with a recent history of interstitial lung disease reported weakness in her arms and legs. Recently she had noticed that she could not climb the 10 steps up from her basement. She had also developed…
In this chapter, we discuss a group of hereditary, often progressive, muscle disorders. These can be categorized as channelopathies, metabolic and mitochondrial myopathies, muscular dystrophies, and congenital myopathies ( Table 70.1 ). TABLE 70.1 Hereditary Myopathies Myopathy Type Locus Gene…
Lambert-Eaton Myasthenic Syndrome Clinical Vignette A 61-year-old woman with no remarkable past medical history developed, over a few months, weakness of her legs with difficulty getting in and out of chairs and climbing stairs. She also experienced significant fatigue. This…
Clinical Vignette A 65-year-old previously healthy man presented to the emergency department for several months of progressive upper extremity weakness and blurry vision. He reports that over the past 3 months, playing the violin and mowing the lawn have become…