General information The family of Krameriaceae contains the single genus Krameria (ratany), species of which have anti-inflammatory [ ], antioxidant [ ], antibacterial [ ], and molluscicidal [ ] actions. You’re Reading a Preview Become a Clinical Tree membership for…
See also Antihistamines General information Ketotifen was originally developed as a drug that would inhibit the release of vasoactive substances from mast cells, as an oral alternative to cromoglicate, but its actions in asthma are probably attributable to its antihistaminic…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Ketorolac is a pyrrolizine carboxylic acid derivative, structurally and pharmacologically related to tolmetin, zomepirac, and indometacin. The trometamol salt of ketorolac enhances its solubility and allows parenteral administration. Opinions on the safety…
General information The spectrum of adverse effects of ketoprofen is similar to that of ibuprofen. Ketoprofen was originally approved for over-the-counter sales in the USA by the FDA, but in the same year, in Italy, the Ministry of Health transferred…
General information The ketolides cethromycin (ABT-773) and telithromycin are semisynthetic derivatives of 14-membered-ring macrolide antibiotics, members of the macrolide-lincosamide-streptogramin-B, MLS(B), class of antimicrobials, but they differ from macrolides by having a 3-keto group instead of an l -cladinose group on…
See also Antifungal azoles [for systemic use] General information Ketoconazole was the first azole available for oral administration, apart from metronidazole. However, it has been supplanted by newer azoles with fewer adverse effects and more reliable absorption from the gastrointestinal…
General information Ketobemidone is an opioid receptor agonist, with pharmacokinetics and potency similar to morphine. Combined with the antispasmodic drug, N,N-dimethyl-3,3-diphenyl-1-methylallylamine chloride, ketobemidone is often used in Scandinavia. In a study of postoperative pain relief, ketobemidone equalled morphine and pethidine…
General information Ketanserin is a selective 5-HT 2 receptor antagonist with antihypertensive action. Because it antagonizes the vasoconstriction and platelet aggregation induced by 5-HT and increases erythrocyte deformability, its potential usefulness in peripheral vascular disease has been extensively investigated, although…
General information Ketamine is a non-competitive antagonist at the phencyclidine site of the N-methyl- d -aspartate (NMDA) receptor for glutamate. However, its effects are also mediated by interactions with many others receptors. It is a short-acting anesthetic that has been…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Kebuzone (ketophenylbutazone, ketazone) is an NSAID that is related to phenylbutazone. Allergic reactions, gastrotoxicity, nephrotoxicity, local reactions with necrosis [ ], and liver damage have been reported [ ]. The Japanese authorities…