See also Benzodiazepines General information Lorazepam is a benzodiazepine with CNS, depressant, anxiolytic, and sedative properties, used as a hypnotic, sedative, and anxiolytic drug. Drug studies Comparative studies In a multicenter, randomized, double-blind comparison of diazepam (0.15 mg/kg followed by…
See also Antihistamines General information Loratadine is a second-generation antihistamine [ ]. Drug studies Placebo-controlled studies Adverse events (including dry mouth, headache, and insomnia) were reported in 30% of those taking loratadine + pseudoephedrine (5 + 120 mg bd for…
See also HIV protease inhibitors General information Lopinavir is a nucleoside analogue reverse transcriptase inhibitor, which is used in combination with ritonavir, another nucleoside analogue reverse transcriptase inhibitor, in the treatment of AIDS. The pharmacology, clinical pharmacology, uses, adverse effects,…
See also Opioid receptor agonists General information Loperamide is an opioid whose action is almost completely restricted to the gut. Recognition of its consequent safety, if it is appropriately used, has led to its being released in many countries for…
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See also Cytotoxic and immunosuppressant drugs General information Lometrexol is a folic acid analogue, 5,10-dideaza-5,6,7,8-tetrahydrofolic acid, which acts as an antifolate drug and targets de novo purine synthesis in tumor cells by inhibiting glycinamide ribonucleotide formyltransferase (GARFT), a folate-dependent enzyme…
See also Fluoroquinolones General information Lomefloxacin is a fluoroquinolone antibacterial drug with actions and uses similar to those of ciprofloxacin. Organs and systems You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…
General information The genera in the family of Loganiaceae ( Table 1 ) include strychnos and trumpet flower. Table 1 The genera of Loganiaceae Fagraea Gelsemium (trumpet flower, jessamine) Labordia (labordia) Mitreola (hornpod) Spigelia (pinkroot) Strychnos (strychnos) You’re Reading a…
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General information Lobeline is derived from the plant Lobelia inflata (Indian tobacco). It is both an agonist and an antagonist at nicotinic receptors, although it is not structurally related to nicotine [ ]. It inhibits nicotine- and amphetamine-induced dopamine release…