General information Phenazopyridine, an azo dye, is used as a urinary tract analgesic. Although its use is not justified, because of toxicity, and although it was, for example, withdrawn in Greece in 1984, it continues to be used [ ,…
General information Phenazone, commonly known as antipyrine, is still used therapeutically in some countries, although it is now used mainly as a marker of hepatic enzyme drug metabolizing activity. It is usually taken in combination with other analgesics, making attributability…
See also Opioid receptor agonists General information Pethidine (meperidine) is about one-tenth as potent as morphine in terms of analgesia. It is metabolized in the liver by hydrolysis and conjugation, either directly or via N-demethylation to norpethidine. Norpethidine (normeperidine) is…
See also Vaccines General information Note on abbreviations DT = Diphtheria + tetanus toxoids DTP = Diphtheria + tetanus toxoids + pertussis DTaP = Diphtheria + tetanus toxoids + acellular pertussis DTwP = Diphtheria + tetanus toxoids + whole cell…
See also Neuroleptic drugs General information Perphenazine is a phenothiazine neuroleptic drug. Drug studies You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
General information Benzoyl peroxide Benzoyl peroxide is an antimicrobial and keratolytic agent used in the treatment of acne; it is also added to some foods. It is a catalyst for cross-linking in the production of plastics and is occasionally used…
See also Angiotensin-converting enzyme inhibitors General information Perindopril is a prodrug ester of perindoprilat, an angiotensin converting enzyme (ACE) inhibitor that has been used in patients with hypertension and heart failure. An updated review of its use in hypertension has…
General information Perhexiline, 2-(2,2-dicyclohexylethyl)piperidine, was originally developed as an antianginal drug in the late 1960s [ ]. However, it caused severe serious adverse reactions, particularly a peripheral neuropathy and hepatotoxicity, in a small proportion of patients, particularly poor CYP2D6 metabolizers,…
General information Pergolide is a dopamine receptor agonist, who adverse effects and reactions resemble those of bromocriptine [ ]. Drug studies Observational studies In 41 patients with Parkinson’s disease who took pergolide, confusion and hallucinations were the adverse reactions that…
See also Hemoglobin-based oxygen-carrying blood substitutes; Ultrasound contrast agents General information Oxygen carriers can be divided into two classes: synthetic perfluorocarbons and hemoglobin-based oxygen carriers, prepared from hemoglobin of human or bovine origin (see separate monograph). It is important for…